Effect of Shaofu Zhuyu Granule on endometrial receptivity of endometriosis (EMs)
少腹逐瘀颗粒对子宫内膜异位症（EMs）内膜容受性作用的研究

摘要

目的 探讨少腹逐瘀颗粒在调节子宫内膜异位症患者子宫内膜容受性中作用及其意义。方法 取2018年01月至2020年12月在本院手术治疗EMs的患者82例，术后根据患者意愿分中药组、对照组两组， 中药组术后给予少腹逐瘀颗粒口服2疗程，再次超声监测子宫内膜容受性相关指标，随访妊娠率；对照组术后同一时间给予上述超声。结果 中药组与其术前比较，VI、FI无统计学差异（P＞0.05），子宫内膜的厚度、子宫内膜的容积、PI、RI、S／D、VFI、均有统计学差异（P＜0.05）；中药组和对照组比较，子宫内膜的容积、子宫内膜的厚度、VI、FI、VFI均无统计学差异（P＞0.05），PI、RI有统计学差异（P＜0.05）。结论 手术治疗有助于EMs患者的子宫内膜容受性相关指标的正向改善，如降低内膜血流阻力和增加内膜下血流灌注；少腹逐瘀颗粒对EMs术后患者的内膜下血流灌注的改善有一定作用。

Abstract

Objective To explore the role and significance of Shaofu Zhuyu Granule in regulating endometrial receptivity in patients with endometriosis.
Methods: 82 patients with EMS who underwent surgery in our hospital from January 2018 to December 2020 were divided into two groups: Traditional Chinese medicine group and control group according to the wishes of the patients. The traditional Chinese medicine group was given Shaofu Zhuyu Granule orally for two courses after operation. The indexes related to endometrial receptivity were monitored by ultrasound again, and the pregnancy rate was followed up; The control group was given the above ultrasound at the same time after operation.
Results: There was no significant difference in VI and fi between the traditional Chinese medicine group and its preoperative group (P > 0.05), but there were significant differences in endometrial thickness, endometrial volume, PI, RI, S / D, VFI and (P < 0.05); Compared with the control group, there was no significant difference in endometrial volume, endometrial thickness, VI, FI and VFI (P > 0.05), but there was significant difference in PI and RI (P < 0.05).
Conclusion  : surgical treatment contributes to the positive improvement of endometrial receptivity in patients with EMS, such as reducing endometrial blood flow resistance and increasing subendometrial blood perfusion; Shaofu Zhuyu Granule has a certain effect on the improvement of subintimal blood perfusion in patients with EMs.