Effect of colchicine combined with dexamethasone on serum uric acid, ESR and oxidative stress in patients with gouty arthritis
秋水仙碱联合地塞米松治疗方案对痛风性关节炎患者血尿酸、血沉及氧化应激指标的影响

摘要

目的 观察秋水仙碱联合地塞米松治疗方案在急性痛风性关节炎治疗中的临床价值。方法 选取急性痛风性关节炎患者86例，收治时间2021年4月-2022年3月。按照随机原则分组，每组43例，对照组予以秋水仙碱治疗，观察组采取秋水仙碱与地塞米松联合用药方案，比较两组治疗情况，包括血尿酸、血沉及氧化应激指标（8-异前列腺素及3-硝基络氨酸修饰蛋白）及用药安全性。结果 治疗后观察组血尿酸、血细胞沉降率以及血肌酐水平均明显下降，比对照组各项指标低（P<0.01），观察组的8-isoPG、3-NT水平明显下降，明显低于对照组（P<0.01）；对照组不良反应发生率为30.2%，观察组为9.3%（P<0.05）。结论 秋水仙碱联合地塞米松治疗方案可显著改善急性痛风性关节炎患者的血尿酸、血沉及氧化应激指标，可有效控制疾病，疗效显著，有较高的临床价值。

Abstract

Objective To observe the clinical value of colchicine combined with dexamethasone in the treatment of acute gouty arthritis.
Methods: 86 patients with acute gouty arthritis were treated from April 2021 to March 2022. According to the random principle, 43 cases in each group were divided into two groups. The control group was treated with colchicine, and the observation group was treated with colchicine and dexamethasone. The treatment conditions of the two groups were compared, including blood uric acid, ESR and oxidative stress indicators (8-Isoprostaglandin and 3-nitrolysine repair protein) and drug safety.
Results: after treatment, the levels of serum uric acid, erythrocyte sedimentation rate and serum creatinine in the observation group were significantly lower than those in the control group (p<0.01). The levels of 8-isopg and 3-NT in the observation group were significantly lower than those in the control group (p<0.01); The incidence of adverse reactions was 30.2% in the control group and 9.3% in the observation group (p<0.05).
Conclusion  : Colchicine combined with dexamethasone can significantly improve the indexes of blood uric acid, ESR and oxidative stress in patients with acute gouty arthritis, and can effectively control the disease. It has significant curative effect and high clinical value.