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Open Access Article

International Journal of Clinical Research. 2022; 6: (6) ; 32-34 ; DOI: 10.12208/j.ijcr.20220251.

Efficacy and safety of oral hormone combined with intrapleural injection of urokinase in the treatment of tuberculous pleurisy
口服激素联合胸腔注射尿激酶治疗结核性胸膜炎的疗效及安全性分析

作者: 王文平 *

遂宁市中心医院 四川遂宁

*通讯作者: 王文平,单位:遂宁市中心医院 四川遂宁;

发布时间: 2022-08-12 总浏览量: 432

摘要

目的 观察口服激素药物联合胸腔内注射尿激酶用药方案治疗结核性胸膜炎的临床价值。方法 选取92例结核性胸膜炎患者作为医学观察样本,收治时间2020年1月-2022年3月。按照随机原则分为对照组和观察组,每组各46例,对照组给予胸腔内注射尿激酶治疗,观察组采取口服激素与胸腔内注射尿激酶联合治疗方案,比较两组临床疗效,评价两种用药方案的安全性。结果 观察组总有效率为95.65%,对照组总有效率80.43%,两组间差异显著(P<0.05)。用药期间观察组出现1例轻微腹胀,发生率2.17%,两组均未出现皮疹、肝功能损伤、发热、胸腔出血及继发感染等不良反应病例。结论 治疗结核性胸膜炎时,采用口服激素与胸腔内注射尿激酶联合治疗方案的临床疗效显著,且安全性较高,患者获益较大,建议推广应用。

关键词: 结核性胸膜炎;胸腔内注射;激素;安全性

Abstract

Objective To observe the clinical value of oral hormone drugs combined with intrapleural injection of urokinase in the treatment of tuberculous pleurisy.
Methods: 92 patients with tuberculous pleurisy were selected as medical observation samples. The treatment time was from January 2020 to March 2022. According to the principle of randomization, they were divided into control group and observation group, with 46 cases in each group. The control group was treated with intrapleural injection of urokinase, and the observation group was treated with oral hormone and intrapleural injection of urokinase. The clinical efficacy of the two groups was compared and the safety of the two drug regimens was evaluated.
Results: the total effective rate was 95.65% in the observation group and 80.43% in the control group. There was significant difference between the two groups (p<0.05). During the treatment period, one case of slight abdominal distension occurred in the observation group, with an incidence of 2.17%. There were no adverse reactions such as skin rash, liver function injury, fever, thoracic hemorrhage and secondary infection in both groups.
Conclusion  : in the treatment of tuberculous pleurisy, the combination of oral hormone and intrapleural injection of urokinase has significant clinical efficacy, high safety and great benefit for patients. It is recommended to popularize it.

Key words: tuberculous pleurisy; Intrathoracic injection; Hormones; Security

参考文献 References

[1] 程凌晨,彭映姝,白浪.胸腔注射尿激酶联合口服醋酸泼尼松治疗结核性胸膜炎的有效性[J].国际流行病学传染病学杂志,2021,48(6):425-430.

[2] 凌婵.地塞米松、尿激酶胸腔注射联合治疗对结核性胸膜炎疗效的影响[J].北方药学,2021,18(3):145-146,153.

[3] 任菊香,刘震霞,韩永战,等.胸腔注射地塞米松治疗结核性渗出性胸膜炎的疗效观察[J].西南国防医药,2019, 29(5):581-583.

[4] 李磊.胸腔置管联合抗结核药治疗结核性胸膜炎患者胸腔积液的疗效分析[J].国际外科学杂志,2018, 45(1): 25-28.

[5] 姜文婷,俞岩.胸腔内注射地塞米松联合尿激酶治疗结核性胸膜炎的临床效果及安全性分析[J].中国医学创新,2022,19(13):46-50.

[6] 曹志红,蒋静,俞珊,等.结核性胸膜炎患者MAIT细胞IFN-γ免疫应答特征及其与疾病转归的相关性[J].临床肺科杂志,2019,24(5):777-781.

[7] 刘枫,杨明娟,杜斌,等.地塞米松联合尿激酶治疗结核性胸膜炎的临床效果分析[J].现代生物医学进展,2017, 17(26): 5138-5140,5193.、

[8] 刘国华.醋酸泼尼松片联合抗结核药物对结核性渗出性胸膜炎患者疗效的影响[J].当代医学,2021,27(2): 137-138.

[9] 曹瑛,马天丽,李俊,等.醋酸泼尼松片结合四联抗结核疗法对结核性胸膜炎的治疗效果[J].河南医学研究, 2021, 30(17):3195-3197.

引用本文

王文平, 口服激素联合胸腔注射尿激酶治疗结核性胸膜炎的疗效及安全性分析[J]. 国际临床研究杂志, 2022; 6: (6) : 32-34.