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Open Access Article

International Journal of Clinical Research. 2022; 6: (6) ; 24-27 ; DOI: 10.12208/j.ijcr.20220249.

Clinical efficacy and safety of silodosin in the treatment of chronic prostatitis
西洛多辛治疗慢性前列腺炎的临床疗效与安全性

作者: 刘中 *

扬州大学医学院 江苏扬州

*通讯作者: 刘中,单位:扬州大学医学院 江苏扬州;

发布时间: 2022-08-12 总浏览量: 667

摘要

目的 评估西洛多辛(4mg和8mg)与安慰剂在慢性前列腺炎中的疗效和安全性。方法 选取我院18岁及以上123例慢性前列腺炎患者,这些患者以前未接受过治疗。将这些患者分为三组,分别服用4mg西洛多辛、8mg西洛多辛和安慰剂,每日一次,持续12周。结果 治疗后,4mg组有效率90.2%,8mg组87.8%,安慰剂组24.4%,4mg和8mg两组有效率与安慰剂组比较差异有统计学意义(P < 0.05),4mg和8mg两组之间有效率比较差异无统计学意义(p>0.05)。治疗后,4mg和8mg两组患者疼痛不适评分、排尿症状评分、生活质量评分均显著降低,治疗前后差异均有统计学意义(P < 0.05)。治疗后,4mg和8mg两组患者前列腺液中IL-10、SIgA、VCAM-1水平均显著降低,治疗前后差异均有统计学意义(P < 0.05),与安慰剂组比较具有统计学意义。在不良反应发生率上,4mg组9.80%,8mg组17.0%,安慰剂组29.3%,三组差异有统计学意义(P < 0.05),结论 西洛多辛4mg或8mg治疗慢性前列腺炎都有很好的疗效,都能显著改善生活质量,降低炎症因子,但西洛多辛4mg的不良反应发生率低,可能有更好的安全性。

关键词: 西洛多辛;慢性前列腺炎;临床疗效;不良反应

Abstract

Objective To evaluate the efficacy and safety of cilodoxine (4mg and 8mg) versus placebo inchronic prostatitis.
Methods: A total of 123 patients, aged 18 or above, who had not been treated before, were divided into three groups and given 4 mg, 8 mg cilodoxineand placebo once a day for 12 weeks
Results: After treatment, the effective rate is 90.2% in the 4mg group, 87.8% in the 8mg group and 24.4% in the placebo group. There are statistically significant differences in effective rates between 4mg and 8mg groups compared with placebo (P<0.05). There is no significant difference in effective rates between 4mg and 8mg groups (P>0.05). After treatment, pain and discomfort scores, urination symptom scores and quality of life scoresin 4mg and 8mg groups are significantly decreased, with statistical significance before and after treatment (P<0.05). After treatment, IL-10,SIgA and VCAM-1levels in prostatic fluid in 4mg and 8mg groups are significantly decreased, with statistical significance before and after treatment compared with placebo(P<0.05). The rate of side effects is 9.80% in the 4mg group, 17.0% in the 8mg group and 29.3% in the placebo group. Thereare statistically significant differences among the three groups(p<0.05).
Conclusion  s: Taking 4mg or 8 mg cilodoxine once a day in the treatment of chronic prostatitis have good efficacy, can significantly improve the quality of life, reduce inflammatory factors, but taking 4 mg has less side effects, it might be more secure.

Key words: Cilodoxine; Chronic prostatitis; Clinical efficacy; Side effect

参考文献 References

[1] Rees J, Abrahams M, Doble A, et al. Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: a consensus guideline[J]. BJU international, 2015, 116(4): 509-525.

[2] Krieger J N, Nyberg Jr L, Nickel J C. NIH consensus definition and classification of prostatitis[J]. Jama, 1999, 282(3): 236-237.

[3] Krieger J N, Nyberg Jr L, Nickel J C. NIH consensus definition and classification of prostatitis[J]. Jama, 1999, 282(3): 236-237.

[4] LI Z, HU J, Xu L I, et al. Mechanism progress of acupuncture and moxibustion for chronic prostatitis: [J]. World Journal of Acupuncture-Moxibustion, 2021, 31(4): 309-313.

[5] MING S, FU Y, HOU W, et al. The effect of sensation of transmission along meridian acupuncture for chronic nonbacterial prostatitis[J]. World Journal of Acupuncture-Moxibustion, 2019, 29(2): 113-118.

[6] Gorpynchenko I, Nurimanov K, Poroshina T, et al. Assessment of Diagnostic Equivalence of Biological Secretions in Men with Chronic Prostatitis/Chronic Pelvic Pain[J]. Journal of Allergy and Clinical Immunology, 2022, 149(2): AB132.

引用本文

刘中, 西洛多辛治疗慢性前列腺炎的临床疗效与安全性[J]. 国际临床研究杂志, 2022; 6: (6) : 24-27.