Application of nalbuphine combined with propofol in painless colonoscopy
纳布啡联合丙泊酚在无痛肠镜中的应用

摘要

目的 探讨和研究纳布啡联合丙泊酚在无痛肠镜中的应用价值和临床疗效。方法 通过回顾和分析了我院2020年4月-2021年7月所接受和收治的无痛肠镜检查的患者住院患者共100例，按照入院的时间顺序进行分组治疗，对照组（50例）给予芬太尼联合丙泊酚麻醉，观察组住院患者(50例)首先接受纳布啡麻醉，然后再配合使用丙泊酚麻醉。两组患者均是采用联合麻醉的方法，最后再比较两组患者的治疗总有效率、VAS评分以及治疗后并发症的发生概率，以此来判断纳布啡联合丙泊酚复合麻醉的临床疗效。结果 观察组患者的治疗总有效率为96.00%，对照组为60.00%；观察组患者并发症的发生发生概率为10.00%，对照组为34.00%；观察组患者的VAS评分明显低于对照组，差异具有统计学意义（p＜0.05）。结论 纳布啡联合丙泊酚干预应用于无痛肠镜检查患者，可将呼吸抑制、恶心呕吐等不良事件的发生率控制在最低限度内，有助于提高治疗总有效率，值得推行运用。

Abstract

Objective: To explore and study the application value and clinical efficacy of nalbuphine combined with propofol in painless colonoscopy.
Methods: A total of 100 inpatients with painless colonoscopy accepted and treated in our hospital from April 2020 to July 2021 were retrospectively analyzed. They were divided into groups according to the chronological order of admission. The control group (50 cases) ) were given fentanyl combined with propofol anesthesia, and the inpatients in the observation group (50 cases) first received nalbuphine anesthesia, and then combined with propofol anesthesia. Both groups of patients were treated with combined anesthesia. Finally, the total effective rate of treatment, VAS score and the incidence of complications after treatment were compared between the two groups to judge the clinical efficacy of nalbuphine combined with propofol combined anesthesia.
Results: The total effective rate of treatment in the observation group was 96.00% and that in the control group was 60.00%; the incidence of complications was 10.00% in the observation group and 34.00% in the control group; the VAS score of the observation group was significantly lower than that of the control group , the difference was statistically significant (p < 0.05).
Conclusion  : The application of nalbuphine combined with propofol intervention in patients with painless colonoscopy can control the incidence of adverse events such as respiratory depression and nausea and vomiting to a minimum, which is helpful to improve the total effective rate of treatment, and is worthy of implementation.