Open Access Article
International Journal of Clinical Research. 2022; 6: (5) ; 120-123 ; DOI: 10.12208/j.ijcr.20220229.
Antibacterial Effect of Compound Antibacterial Agent on the Foodborne pathogens
复配抑菌剂对食源性致病菌的抑菌作用研究
作者：
罗娜,
米其利,
刘华银,
徐晓鑫,
高茜,
邓亮 *
昆明医科大学 药学院暨云南省天然药物药理重点实验室 云南昆明
云南中烟工业股份有限公司 云南省烟草化学重点实验室 云南昆明
*通讯作者：
邓亮,单位：昆明医科大学 药学院暨云南省天然药物药理重点实验室 云南昆明；
发布时间: 2022-07-18 总浏览量: 405
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万方数据（WANFANG DATA）
摘要
从12种中药中筛选出分别对两种食源性致病菌抑制效果最强的三种中药，采用响应面优化法优化复合抑菌剂对两种食源性致病菌的抑菌效果。结果表明金黄色葡萄球菌抑制效果最优为：鱼腥草4.49份，夏枯草4.35份，五倍子1.96份，预测抑菌圈为14.7941mm。大肠杆菌抑制效果最优为：鱼腥草提4.53份，甘草4.43份，毛冬青2.44份，预测抑菌圈为14.2088mm；因此，采用响应面优化所得的复配抑菌剂对两种食源性致病菌有较好的抑制作用。
关键词： 复配抑菌剂；食源性致病菌；抑菌
Abstract
Three Chinese medicines with the strongest inhibitory effect on two foodborne pathogenic bacteria were screened out from 12 kinds of Chinese medicines. Response surface optimization method was used to optimize the antibacterial effect of compound antibacterial agent on two foodborne pathogenic bacteria. The results showed that the optimal inhibitory effect of STaphylococcus aureus was 4.49 houttuynia cordata, 4.35 Prunella subtilis and 1.96 Galla chinensis. The predicted inhibition zone was 14.7941mm. The best inhibitory effect was 4.53 houttuynia cordata extracts, 4.43 licorice extracts and 2.44 Holly extracts. The predicted inhibition zone was 14.2088mm. Therefore, the compound bacteriostatic agent obtained by response surface optimization has a good inhibitory effect on the two foodborne pathogenic bacteria.
Key words： Compound Antibacterial Agent; Foodborne Pathogens; Bacteriostatic
参考文献 References
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引用本文
罗娜, 米其利, 刘华银, 徐晓鑫, 高茜, 邓亮, 复配抑菌剂对食源性致病菌的抑菌作用研究[J]. 国际临床研究杂志, 2022; 6: (5) : 120-123.