摘要
目的 探讨能否通过康复新液外涂减轻乳腺癌患者应用盐酸多柔比星脂质体致手足综合征的发生率、严重程度及发生时间。方法 选取2019年10月至2021年12月在河北省邢台市人民医院乳腺外科住院进行盐酸多柔比星脂质体治疗的乳腺癌患者80例，随机分为两组，每组40人。研究组给予康复新液手足外涂进行干预，对照组无特殊干预措施。比较两组手足综合征发生的相关情况。结果 研究组手足综合征发生率及严重程度显著低于对照组（P＜0.05）。结论 康复新液外用可减轻乳腺癌患者应用盐酸多柔比星脂质体所致手足综合征的发生率及严重程度。
关键词： 康复新液；乳腺癌；手足综合征；盐酸多柔比星脂质体；化疗
Abstract
Objective To explore whether the external application of Kangfuxin liquid can reduce the incidence, severity and occurrence time of hand-foot syndrome induced by doxorubicin hydrochloride liposome in breast cancer patients. Methods A total of 80 patients with breast cancer who received doxorubicin hydrochloride liposome treatment in the Breast Surgery Department of Xingtai People's Hospital, Hebei Province from October 2019 to December 2021 were selected and randomly divided into two groups with 40 patients in each group. The research group was given Kangfuxin liquid external application on hands and feet for intervention, and the control group had no special intervention measures. The incidence of hand-foot syndrome in the two groups was compared. Results The incidence and severity of hand-foot syndrome in the study group were significantly lower than those in the control group (P<0.05). Conclusion External application of Kangfuxin Liquid can reduce the incidence and severity of hand-foot syndrome caused by doxorubicin hydrochloride liposome in breast cancer patients.
Key words： Kangfuxin Liquid; Breast Cancer; Hand-Foot Syndrome; Doxorubicin Hydrochloride Liposome; Chemotherapy
参考文献 References
[1] 谢雨礼与苏红, 抗肿瘤药物多柔比星脂质体. 药学与临床研究, 2010. 18(002)： 第107-111页.
[2] 王晓稼, 重视乳腺癌患者的血脂管理. 中国医刊, 2019. 54(8)： 第4页.
[3] 胡夕春等, 中国蒽环类药物治疗乳腺癌专家共识. 中国肿瘤临床, 2018. 45(3)： 第6页.
[4] Rafiyath, S.M., M. Rasul and B. Lee, Comparison of safety and toxicity of liposomal doxorubicin vs. conventional anthracyclines: a meta-analysis. Experimental Hematology & Oncology, 2012. 1(1): p. 1-9.
[5] Arnoud, et al., Prevention of palmar–plantar erythrodysesthesia with an antiperspirant in breast cancer patients treated with pegylated liposomal doxorubicin (SAKK 92/08). Breast, 2014.
[6] Miller, K. K., L. Gorcey and B. N. Mclellan, Chemotherapy- induced hand-foot syndrome andnailchanges: A review of clinical presentation, etiology, pathogenesis, and management. Journal of the American Academy of Dermatology, 2014. 71(4)： p. 787-794.
[7] Von Moos, R., et al., Pegylated liposomal doxorubicin- associated hand-foot syndrome: Recommendations of an international panel of experts. EUROPEAN JOURNAL OF CANCER, 2008.
[8] Freites-Martinez, A., et al., Using the Common Terminology Criteria for Adverse Events (CTCAE – Version 5.0) to Evaluate the Severity of Adverse Events of Anticancer Therapies. Actas Dermo-Sifiliográficas, 2020. 112(1).
[9] Martschick, A., et al., The pathogenetic mechanism of anthracycline-induced palmar-plantar erythrodysesthesia. Anticancer research, 2009. 29(6)： p. 2307-2313.
[10] 丁娟与王虹, PDCA循环结合四位一体模式在乳腺癌术后患肢功能康复中的应用效果. 中华现代护理杂志, 2016(7)： 第4页.
[11] 张汉超等, 康复新液药理作用及临床应用的研究进展. 中国民族民间医药, 2017(3)： 第4页.
[12] 张蝶, 康复新液治疗压疮的临床应用及实验研究进展. 世界最新医学信息文摘, 2016.
[13] 刘玉媛, 天然药物康复新液的临床应用. 天津药学, 2006. 18(3)： 第3页.
[14] 李治纲与朱辉, 康复新液化学成分及药理活性研究进展. 世界最新医学信息文摘, 2019(94)： 第2页.