Effect of prolonged intravenous infusion time of meropenem on the efficacy and safety of patients with severe infection
延长美罗培南静脉输注时间对治疗重症感染患者的有效性和安全性的影响

摘要

目的 探讨重症感染患者治疗中延长美罗培南静脉输注时间对治疗有效性和安全性的影响。方法 回顾性选取2020年2月-2021年2月本院重症感染患者60例，依据美罗培南静脉输注时间分为延长组、常规组两组，各30例，统计分析两组体温、实验室理化指标、SOFA评分、临床疗效、不良反应发生情况。结果 用药前，两组患者的体温、PCT水平、WBC、SOFA评分之间的差异均不显著（P>0.05），用药后，延长组患者的体温、PCT水平、WBC、SOFA评分均低于常规组（P<0.05）；两组患者用药后的体温、PCT水平、WBC、SOFA评分均低于用药前（P<0.05）。延长组患者的总有效率80.00%（24/30）高于常规组53.33%（16/30）（χ2=4.800，P<0.05）。两组患者的不良反应发生率26.67%（8/30）、23.33%（7/30）之间的差异不显著（χ2=0.089，P<0.05）。结论 重症感染患者治疗中延长美罗培南静脉输注时间能够进一步提升治疗有效性和安全性。

Abstract

Objective To investigate the effect of prolonged intravenous infusion time of meropenem on the efficacy and safety of patients with severe infection.
Methods: From February 2020 to February 2021, 60 patients with severe infection in our hospital were retrospectively selected, and they were divided into the extended group and the routine group according to the intravenous infusion time of meropenem, with 30 cases in each group. Laboratory physical and chemical indicators, SOFA score, clinical efficacy, adverse reactions.
Results: Before medication, the differences in body temperature, PCT level, WBC, and SOFA scores between the two groups were not significant (P>0.05). The routine group (P<0.05); the body temperature, PCT level, WBC and SOFA scores of the two groups of patients after treatment were lower than those before treatment (P<0.05). The total effective rate of the patients in the extension group was 80.00% (24/30), which was higher than that in the conventional group, which was 53.33% (16/30) (χ2=4.800, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups, 26.67% (8/30) and 23.33% (7/30) (χ2=0.089, P<0.05).
Conclusion  : Prolonging the intravenous infusion time of meropenem in the treatment of severe infection patients can further improve the efficacy and safety of the treatment.