Clinical observation and prognostic effect of different radiotherapy methods in the treatment of locally advanced nasopharyngeal carcinoma
不同放射治疗方式治疗局部晚期鼻咽癌的临床观察及预后效果探究

摘要

目的 分析不同放射治疗方式治疗局部晚期鼻咽癌的临床观察及预后效果。方法 选择我院2012年1月到2021年12月局部晚期鼻咽癌患者共78例，数字表随机分2组每组39例，对照组的患者给予常规放射治疗方案，观察组采取调强适形放射治疗。比较两组治疗前后患者生存质量的相关评分、放射治疗副作用发生率、总缓解率。结果 治疗前二组患者生存质量的相关评分比较，P＞0.05，而治疗后两组生存质量的相关评分均升高，而观察组生存质量的相关评分显著高于对照组，P＜0.05。观察组放射治疗副作用发生率显著低于对照组，P＜0.05。观察组总缓解率显著高于对照组，P＜0.05。结论 局部晚期鼻咽癌的同时给予调强适形放射治疗，可有效减少放射治疗副作用的发生，提高患者的生存质量和提高疗效，值得推广。

Abstract

Objective: To analyze the clinical observation and prognosis of different radiotherapy for locally advanced NASOPHARYNGEAL Carcinoma.
Methods: from January 2012 to December 2012,78 patients with locally advanced NASOPHARYNGEAL carcinoma were randomly divided into 2 groups (39 cases in each group), the control group (39 cases in each group) received conventional radiotherapy and the observation group (38 cases in each group) received intensity modulated radiation therapy (imrt). The quality of life (Qol), the incidence of side effects and the total remission rate were compared between the two groups.
Results: Before treatment, the correlation scores of Qol in the two groups were significantly higher than those in the control group (p < 0.05) , while after treatment, the correlation scores of Qol in the observation group were significantly higher than those in the control group (p < 0.05). The incidence of side effects in the observation group was significantly lower than that in the control group (p < 0.05). The total remission rate of the observation group was significantly higher than that of the control group (p < 0.05).
Conclusion  : Intensity modulated radiation therapy (IMRT) combined with local advanced nasopharyngeal Carcinoma (NPC) can effectively reduce the side effects of radiotherapy, improve the quality of life and improve the curative effect.