期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Clinical Research. 2022; 6: (5) ; 7-11 ; DOI: 10.12208/j.ijcr.20220194.

Application of ferritin in hemophagocytic syndrome
铁蛋白在噬血细胞综合征中的应用

作者: 陈岚, 李叶琼, 冶秀鹏 *

宁夏医科大学附属第三临床学院(宁夏回族自治区人民医院) 宁夏银川

*通讯作者: 冶秀鹏,单位:宁夏医科大学附属第三临床学院(宁夏回族自治区人民医院) 宁夏银川;

发布时间: 2022-07-13 总浏览量: 502

摘要

噬血细胞综合征又称噬血细胞性淋巴组织细胞增生症(hemophagocytic lymphohistocytosis, HLH),是由遗传性或获得性免疫调节异常导致的过度炎症反应综合征,发病率低,病死率高,进展迅速,严重可危及生命。其诊断的非特异性特点,使其易与众多疾病混淆,从而延误诊断和治疗。血清铁蛋白通常和HLH疾病活动度呈正相关,在HLH的早期诊断和治疗监测中有重要意义。本文着重对HLH的诊断、实验室检查,尤其铁蛋白应用及治疗新进展进行综述。

关键词: 噬血细胞综合征;实验室检查;铁蛋白;治疗

Abstract

Hemophagocytic syndrome, also known as hemophagocytic lymphohistocytosis (HLH), which is an excessive inflammatory response syndrome caused by genetic or acquired immune regulation. It has low incidence rate, high mortality rate, and rapid progress, which can seriously endanger life. It is easy to be confused bacause of nonspecific diagnosis, thus delaying the diagnosis and treatment. Serum ferritin is usually positively correlated with HLH disease activity, which is of great significance in the early diagnosis, treatment and monitoring of HLH. This paper focuses on review the diagnosis and laboratory examination of HLH, especially the application of ferritin and advance in treatment in HLH.

Key words: Hemophagocytic syndrome; Laboratory examination; Ferritin; Treatment

参考文献 References

[1] 祝鹏英,么颖,柴艳芬.噬血细胞综合征1例临床报告分析及文献复习[J].实用临床护理学电子杂志,2020,5(7):136.

[2] Chen TY,Hsu MH,et al.Outcome analysis of pediatric hemophagocytic lymphohistiocytosis[J].J Formos Med Assoc, 2021,120(1 Pt 1):172-179.

[3] Bi SH, Jiang LL,Dai LY, Wang LL,et al.Familial hemophagocytic lymphohistiocytosis type 2 in a female Chinese neonate:A case report and review of the literature[J].World J Clin Cases,2021,9(21):6056-6066.

[4] 张婷.噬血细胞综合征治疗进展[J].医学信息,2019, 32(22): 46-48.

[5] 刘香君,张红宾.噬血细胞综合征的诊治进展[J].现代医药卫生,2019,35(19):3012-3015.

[6] Fardet L, Galicier L, Lambotte O, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome[J].Arthritis Rheumatol. 2014, 66(9):2613-20.

[7] Otrock ZK, Eby CS. Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis[J]. Am J Hematol, 2015, 90(3): 220-4. 

[8] 邹文婷,青胜兰,张娜,等.8例成人噬血细胞综合征临床分析[J].黑龙江医学,2021,45(1):44-46,48.

[9] 高伟波,石茂静,张海燕,等.显著高铁蛋白血症与噬血细胞性淋巴组织细胞增多症的相互关系[J].北京大学学报(医学版),2021,53(5):921-927. 

[10] Wen Qi Cher,Ragavendra Kalyanasundaram, Mei Yoke Chan,et al.Profound hyperferritinemia may not be specfc for the diagnosis of haemophagocytic lymphohistiocytoss (HLH) in Asian children[J]. Pediatric Hematology Oncology Journal,2020,5(3):96-99.

[11] Kohli S,Chadha R,Rastogi N,et al.High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis[J].eJHaem,2021,2(1):94-96.

[12] Abou Shaar R,Eby CS,van Dorp S,et al.Increasing ferritin predicts early death in adult hemophagocytic lymphohistiocytosis[J]. Int J Lab Hematol,2021,00:1-8.

[13] Lee SB, Cha J, Kim IK, et al.A high-throughput assay of NK cell activity in whole blood and its clinical application[J]. Biochem Biophys Res Commun, 2014, 445(3): 584-90.

[14] Oh EJ, Yoon JH, Park KH, et al. Natural-killer cell cytotoxicity as a diagnostic and prognostic marker for adult patients with secondary hemophagocytic lymphohistiocytosis:a prospective phase II observational study[J]. Ther Adv Hematol,2021,12.

[15] Lee H, Kim HS, Lee JM, et al. Natural killer cell function tests by flowcytometry-based cytotoxicity and IFN-γ production for the diagnosis of adult hemophagocytic lymphohistiocytosis[J]. Int J Mol Sci,2019,20(21):5413.

[16] Naymagon L,Tremblay D, Troy K, et al. Soluble interleukin‐2 receptor (sIL‐2r) level is a limited test for the diagnosis of adult secondary hemophagocytic lymphohistiocytosis[J]. European journal of haematology, 2020, 105(3): 255-261.

[17] 董文渊,楼方,舒秀兰,等.血清白细胞介素-2及可溶性白细胞介素-2受体水平对儿童感染相关性噬血细胞综合征的诊断及与预后相关性的研究[J].实用医院临床杂志,2020,17(4):44-47.

[18] Zhang FJ, Huang GQ, Li J, et al. Clinical characteristics ofadult hemophagocytic lymphohistiocytosis in the emergency department[J]. Int J Gen Med, 2021, 14: 4687-4694.

[19] Kwak A, Jung N, Shim YJ, et al. A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults[J]. Yeungnam Univ J Med, 2021,38(3):208-218.

[20] 沈子园,贺晨露,孙倩,等.124例成人噬血细胞综合征临床预后分析:一项淮海淋巴瘤协作组多中心回顾性研究.中华血液学杂志,2021,42(10):800-806.

[21] 黄亮.18例噬血细胞综合征临床特点分析[J].江西医药,2019,54(7),772-774,780.

[22] Nandhakumar D,Loganatha A,Sivasankaran M,et al. Hemophagocytic Lymphohistiocytosis in Children[J]. Indian J Pediatr, 2020,87(7):526-531.

[23] 李佩章,王英,黄玲莎,等.铁蛋白和纤维蛋白原在噬血细胞综合征疗效评价中的意义[J]. 医学研究杂志,2016(3),58-60.

[24] 贺小慧,钱素云,李志刚,等.细菌相关性噬血细胞综合征的研究进展[J].中国小儿急救医学,2018,25(11):849-853.

[25] Zhou J,Zhou J,Wu ZQ,et al.Ferritin index is a strong prognostic marker in adult hemophagocytic lymphohistiocytosis[J].I nternational journal of clinical practice, 2021, 75(3):e13704.

[26] Zhou YH, Han XR, Xia FQ, et al. Clinical features and prognostic factors of early outcome in pediatric hemophagocytic lymphohistiocytosis:a retrospective analysis of 227 Cases[J].J Pediatr Hematol Oncol, 2022, 44(1): e217-e222.

[27] Bichon A, BourrenneJ, Allardet-serventJ,et al.Features of hemophagocytic lymphohistiocytosis in the intensive care unit (ICU):a 260-patient retrospective analysis[J].2021.

[28] Wang J, Wang Y, Wu L, et al. Ruxolitinib for refractory/ relapsed hemophagocytic lymphohistiocytosis[J]. Haematologica, 2020, 105(5): e210-e212. 

[29] Bhatt NS, Oshrine B, An Talano J. Hemophagocytic lymphohistiocytosis in adults[J]. Leuk Lymphoma, 2019, 60(1):19-28. 

[30] Ghosh S, Carmo M, Calero-Garcia M, et al. T-cell gene therapy for perforin deficiency corrects cytotocity defects and prevents hemophagocytic lymphohiscytosis manifestations[J]. J Allergy Clin Immunol, 2018, 142: 904-913.

引用本文

陈岚, 李叶琼, 冶秀鹏, 铁蛋白在噬血细胞综合征中的应用[J]. 国际临床研究杂志, 2022; 6: (5) : 7-11.