摘要
目的 基于真实世界四川省人口健康信息平台数据，探讨四川省卵圆孔未闭的患病状况、合并症情况和相关因素。方法 在四川省人口健康信息平台中，提取2016年全年房间隔病变患者资料，共提取完整资料13459份。结果 在13459例患者中，房间隔缺损9217例，小于3岁生理性卵圆孔未闭3809例，PFO的患者为433例，比较差异有统计学意义（P<0.05）。433例PFO中，儿童46例，中青年220例，老年组167例，三组比较有统计学差异（P<0.05）。PFO的儿童合并症表现为肺部感染15例（22.73%），心肌病8例（12.12%），心功能衰竭13例（19.70%）。在PFO成人合并症中，表现为心肺病变患病率高，老年组冠心病78例（46.7%），心功能衰竭65例（42.21%），肺部感染41例（24.5%），均高于中青年组，比较差异有统计学意义（P<0.05）。老年组PFO合并缺血性脑卒中患病率为25.1%，中青年组患病率仅8.2%，两组比较有统计学意义（P<0.05）。PFO合并头痛的患病比率不高，在老年组比率为1.2%，中青年组为2.7%，两组比较无统计学意义（P>0.05）。结论 PFO的合并症以心肺疾病患病率高。PFO与缺血性脑卒中的患病有年龄相关性，PFO合并偏头痛患病率不高。
关键词： 卵圆孔未闭；经胸心脏彩超检查；缺血性脑卒中；偏头痛；人口健康信息平台
Abstract
Aims To explore the incidence,thecomplications and related factors for patient foramen ovale(PFO) in Sichuan province based on the data in real world Sichuan provincial population health information platform database. Methods The date ofpopulation health information platform in Sichuan province were retrieved, to choose Septal lesions cases in 2015 all year. There were totally 13459 cases retrieved out. Results In the all 13459 cases, there were 9217 cases of Atrial Septal Defect, less than 3 years old physiological foramen ovale were registered in 3809 cases (28.2%), more than 3 years old patients with PFO is 433 cases(3.2%)(P<0.05).433 patients with PFO, 46 cases of children (10.62%), young and middle-aged 220 (50.08%), the older group 167 cases (39.3%), three groups were statistically significant ((P<0.05). PFO complications in adults, characterized by high incidence of heart and lung disease, there are 78 cases of coronary heart disease (46.7%), 44 cases of atrial fibrillation (26.3%), 70 cases of heart failure (41.9%),) pulmonary infection in 41 cases (24.5%) in older group, were higher than the younger group(P<0.05). There were 69 cases of hypertension (41.3%), 30 cases of peripheral vascular atherosclerotic plaque (17.9%) in older group too, were higher than the younger group (P<0.05).The incidence rate of PFO in old group complicated with ischemic cerebral apoplexy was25.1%, young group rate was only 8.2%, the older group higher than the youth group ((P<0.05). The incidence rate ofPFO with headaches is not high, older group was 1.2%, and young groups as 2.7%, the two groups was not statistically significant (P>0.05). Conclusion The incidence of PFO in different age groups were different, the high incidence of complications in PFO were heart disease and lung disease, there were no association about age between PFO and cerebral ischemic stroke, there were low incidence of PFO with migraines.
Key words： Patent Foramen Ovale (PFO); Transthoracic Echocardiography；Cerebral Ischemic Stroke; Migraine; Provincial Population Health Information Platform
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