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Open Access Article

International Journal of Clinical Research. 2022; 6: (2) ; 49-54 ; DOI: 10.12208/j.ijcr.20220054.

Research progress of Asparaginase Toxicity in the Treatment of Children with Acute Lymphoblastic Leukemia
儿童急淋化疗中门冬酰胺酶相关不良反应的研究进展

作者: 范林 *, 于洁

重庆医科大学附属儿童医院 重庆

*通讯作者: 范林,单位:重庆医科大学附属儿童医院 重庆;

发布时间: 2022-04-24 总浏览量: 676

摘要

门冬酰胺酶(Asp)是急性淋巴细胞性白血病(ALL)联合化疗中的关键药物,自临床应用以来,儿童急淋的总体生存率(OS)及长期无事件生存率(EFS)都有了很大程度的提高。然而其在发挥治疗作用的同时还会产生多种不良反应,如超敏反应、胰腺炎、血栓等,导致部分患儿Asp的截断,甚至死亡。

关键词: 门冬酰胺酶;超敏反应;门冬酰胺相关性胰腺炎;肝脏毒性血栓

Abstract

Asparaginase (Asp) is a key drug in the combined chemotherapy of acute lymphoblastic leukemia (ALL). Since its clinical application, the overall survival rate (OS) and long-term event free survival rate (EFS) of children with acute lymphoblastic leukemia have been greatly improved. However, while it plays a therapeutic role, it will also produce a variety of toxicity, such as hypersensitivity, pancreatitis, thrombosis, etc.,leading to the truncation of Asp in some children and even death.

Key words: Asparaginase; Hypersensitivity; Asparagine-associated-pancreatitis; Hepatotoxic thrombosis

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引用本文

范林, 于洁, 儿童急淋化疗中门冬酰胺酶相关不良反应的研究进展[J]. 国际临床研究杂志, 2022; 6: (2) : 49-54.