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当前位置：国际临床研究杂志 > 2022年 6卷 (1)期

Open Access Article

International Journal of Clinical Research. 2022; 6: (1) ; 13-18 ; DOI: 10.12208/j.ijcr.20220025.

Quantitative hepatitis B surface antigen levels in patients co-infected with hepatitis B and human immunodeficiency virus after 2 years of combined antiretroviral therapy
HIV/HBV共感染者抗病毒治疗2年HBsAg水平监测的相关研究

作者： 李冰洁, 钱克莉 *, 田小星

重庆市第五人民医院感染性疾病科重庆

重庆医科大学附属第一医院重庆

*通讯作者：钱克莉,单位：重庆医科大学附属第一医院重庆；

重庆市南岸区卫计委科研项目

发布时间: 2022-01-12 总浏览量: 710

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摘要

目的探讨HBsAg定量检测在HIV/HBV共感染者抗病毒治疗过程中的变化。方法观察随访36例HIV/HBV共感染患者在接受含替诺福韦及拉米夫定方案的抗逆转录病毒治疗后HBsAg及相关指标改变情况。结果 HBeAg阳性患者在治疗2年后HBsAg水平下降0.93 log IU/mL，HBeAg阴性患者仅有0.56 log IU/mL。10例(45%)HBeAg阳性患者治疗后出现HBeAg阴转，其中2例出现HBsAg阴转。HBsAg水平与CD4+T淋巴细胞计数水平相关。抗病毒治疗后CD4+T淋巴细胞计数上升明显患者HBsAg水平下降较明显。结论 HBsAg在治疗早期的下降趋势可以预测HBsAg清除可能以及HBsAg下降与CD4+T淋巴细胞计数水平改变相关性均提示HBsAg水平与患者免疫状态相关。

关键词： HIV/HBV共感染；高效抗逆转录病毒治疗

Abstract

Objective To investigate the changes of HBsAg in patients coinfected with HBV and human immunodeficiency virus (HIV) who receive antiviral therapy.
Methods To observe the changes of HBsAg and related indexes in 36 HBV/HIV co-infected patients after receiving antiretroviral therapy containing tenofovir and lamivudine.
Results Baseline and on treatment parameters were associated with longitudinal HBsAg levels. HBeAg–positive patients achieved a decline of 0.93 log IU/mL in HBsAg, whereas HBeAg-negative patients only achieved a decline of 0.56 log IU/mL during 2years of cART. 10(45%) patients of the HBeAg-positive population achieved HBeAg loss and 2(5%) achieved HBsAg loss. HBsAg levels correlated with CD4 T-cell counts. HBsAg levels were significantly lower in patients who had a stronger increase between nadir CD4 and current CD4 T-cell counts during cART. HBsAg decline is dependent on an effective immune status.
Conclusion HBsAg kinetics early during treatment were predictive of HBsAg seroclearance and correlated with an increased CD4 T-cell counts, underlining the importance of immune restoration in HBV clearance.

Key words： HIV/HBV co-infection; HAART

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引用本文

李冰洁, 钱克莉, 田小星, HIV/HBV共感染者抗病毒治疗2年HBsAg水平监测的相关研究[J]. 国际临床研究杂志, 2022; 6: (1) : 13-18.