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Open Access Article

International Journal of Clinical Research. 2021; 5: (4) ; 93-98 ; DOI: 10.12208/j.ijcr.20210051.

Mechanism of brain injury and long-term neurodevelopmental impairmentin neonatal purulent meningitis
新生儿化脓性脑膜炎脑损伤机制及长期神经发育损害

作者: 尤海容 , 邓春*,

重庆医科大学附属儿童医院 重庆

*通讯作者: 邓春,单位:重庆医科大学附属儿童医院 重庆;

发布时间: 2021-12-10 总浏览量: 276

摘要

血脑屏障的破坏、小胶质细胞激活、炎症损伤会对早期大脑发育产生不利影响,导致婴儿的长期神经损伤。在新生儿中预防感染、早期管理、密切随访和早期干预的策略仍然是改善结果的基础。

关键词: 新生儿;化脓性脑膜炎;脑损伤;小胶质细胞;炎症;神经发育损害

Abstract

The destruction of blood-brain barrier, activation of microglia and inflammatory injury will have adverse effects on early brain development and lead to long-term nerve injury in infants. Strategies for infection prevention, early management, close follow-up and early intervention in newborns remain the basis for improving outcomes.

Key words: Newborn; Purulent Meningitis; Brain Damage; Microglia; Inflammation; Neurodevelopmental Damage

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引用本文

尤海容 , 邓春, 新生儿化脓性脑膜炎脑损伤机制及长期神经发育损害[J]. 国际临床研究杂志, 2021; 5: (4) : 93-98.