欢迎来到OAJRC平台！
登录 | 注册 | English
期刊目次
加入编委
添加您的邮件地址以接收即将发行期刊数据：
Open Access Article
International Journal of Clinical Research. 2021; 5: (2) ; 6-10 ; DOI: 10.12208/j.ijcr.20210016.
东南大学医学院附属江阴医院神经内科二科 江苏江阴
*通讯作者： 孔玉,单位：东南大学医学院附属江阴医院神经内科二科 江苏江阴；
发布时间: 2021-05-31 总浏览量: 1387
PDF 全文下载 引用本文 收录截图（CNKI-Scholar）
目的 评价尤瑞克林联合丹参酮IIA治疗急性脑梗死的临床效果。方法 选择2018年1月~2020年2月50例急性脑梗死（ACI）患者，随机均分为观察组和对照组。两组均采用降低颅内压、神经保护剂、改善微循环、抗感染等基础治疗，对照组给予尤瑞克林0.15PNAU/次，qd，观察组给予尤瑞克林0.15PNAU/次，qd，联合丹参酮IIA 60mg/次，qd，两组均治疗2w。比较两组神经功能（神经功能缺损-NIHSS评分）和日常生活能力（ADL评分），观察两组疗效和炎性因子（IL-6、TNF-α）变化。结果 观察组NIHSS评分明显低于对照组（P<0.05），ADL评分显著高于对照组（P<0.05）。观察组治疗有效率为100.00%，显著高于对照组的72.00%（P<0.05）。观察组IL-6、TNF-α明显低于对照组（P<0.05）。结论 尤瑞克林联合丹参酮IIA明显改善ACI患者的神经功能，提高日常生活能力和疗效，抑制炎性反应。
Objective To evaluate the clinical effect of urinary kallid combined with tanshinone IIA in the treatment of acute cerebral infarction. Methods: 50 patients with acute cerebral infarction (ACI), selected from January 2018 to February 2020, were randomly divided into the observation group and the control group,25 cases in each group. Patients were received reducing intracranial pressure,neuroprotection, improving microcirculation and anti-infection therapy in the two groups. Patients in the control group were given urinary kallid 0.15PNAU/times,qd, patients in the observation group were received urinary kallid 0.15PNAU/time combined with tanshinone IIA 60mg/time,qd respectively. The therapy would be two weeks in each group. The neurologic impairment(NIHSS scores) and ability of activities of daily living (ADL scores) were compared in the two groups. The curative effect and the changes of inflammatory factors (IL-6,TNF-α) were observed in the two groups. Results: NIHSS scores in the observation group were significantly lower than those in the control group (P<0.05), and ADL scores in the observation group were significantly higher than those in the control group (P<0.05). The effective rate in the observation group was 100.00%, which was significantly higher than that (72.00%) in the control group (P<0.05). IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P<0.05). Conclusion : Urinary kallid combined with tanshinone IIA could significantly improve neurological function, improve the ability of daily living andefficacy, inhibit the inflammatory response in patients with ACI.
[1] Amarenco P,Albers GW,Denison H,et al. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin:a subgroup analysis of SOCRATES,a randomised,double-blind,controlled trial[J].Lancet Neurol,2017 16 (4) : 301-310.
[2] Lapergue B, Blanc R, Gory B, et al. Effect of Endovascular Contact Aspiration vs Stent Retriever on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion: The ASTER Randomized Clinical Trial[J].JAMA,2017 318 (5) : 443-452.
[3] Weber R, Nordmeyer H, Hadisurya J, et al. Comparison of outcome and interventional complication rate in patients with acute stroke treated with mechanical thrombectomy with and without bridging thrombolysis[J].J Neurointerv Surg,2017 9 (3) : 229-233.
[4] 陆婉杏,罗章伟,蒙兰青. 尤瑞克林治疗急性脑梗死的疗效及对日常功能的改善效果[J].中国实用神经疾病杂志,2016 19 (1) : 50-51.
[5] Wang YX, Chen Y, Zhang CH, et al. Study on the effect of urinary kallidinogenase after thrombolytic treatment for acute cerebral infarction[J].Eur Rev Med Pharmacol Sci,2015 19 (6) : 1009-1012.
[6] 张渭芳，赵康仁，任乃勇等. 尤瑞克林治疗急性脑梗死后吞咽功能障碍的疗效分析[J].临床神经病学杂志,2016 29 (6) : 459-461 .
[7] 孔繁鑫,虢周科. 脑髓康方配合尤瑞克林治疗非溶栓急性期脑梗死临床观察[J].山西中医,2016 32 (6) : 6-8.
[8] 张申,刘喜灿,赵丹鹏,等. 尤瑞克林联合阿司匹林治疗急性脑梗死的临床研究[J].中国临床药理学杂志,2016 32 (16) : 1449-1452.
[9] 邹锡良. 丹参酮IIA磺酸钠对急性脑梗死患者血白细胞介素6和神经功能的影响[J].中国实用神经疾病杂志,2015 18 (4) : 72-73.
[10] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组. 中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010 43 (2) : 146-153.
[11] Brott T, Adams H P Jr, Olinger C P, et al. Measurementsof acute cerebral infarction: a clinical examination scale[J].Stroke,1989 20 (7) : 864-870.
[12] 张明圆. 精神科评定量表手册[M].长沙:湖南科学技术出版社,1998 : 166.
[13] 王广梅,沈洋,张林. 丹参酮ⅡA磺酸钠对急性脑梗死患者凝血功能、血液流变学的影响及机制探讨[J].中医药导报,2016 22 (24) : 94-96.
[14] 黄华栋,施伟红,李冬辉,等. 丁苯酞胶囊联合刺五加治疗急性脑梗死的临床研究[J].中国临床药理学杂志,2016 32 (24) : 2218-2221.
[15] Nagano H, Suzuki T, Nakamura S, et al. Pharmacological studies on human urinary kallidinogenase (SK-827): cerebral protective effects[J].Yakugaku Zasshi,1993 113 (11) : 803-809.
[16] Chen WY, Mao FC, Liu CH, et al. Chromium supplementation improved post-stroke brain infarction and hyperglycemia[J].Metab Brain Dis,2016 31 (2) : 289-297.
[17] 赵勇,郑水洁. 尤瑞克林联合疏血通治疗急性进展性脑梗死的疗效及CT评价[J].长春中医药大学学报,2017 33 (1) : 133-135.
[18] 蔡发良. 醒脑静联合尤瑞克林治疗急性脑梗死的临床研究[J].实用临床医药杂志,2016 20 (13) : 147-148.
[19] 李龙珠,刘家军,张梅,等. 丹参酮IIA磺酸钠联合依达拉奉对脑梗死局部脑血流及血液流变学影响[J].辽宁中医药大学学报,2016 18 (2) : 182-184.
[20] Zhou L, Zhang J, Wang C, et al. Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model[J].Int J Immunopathol Pharmacol,2017 30 (2) : 123-129.
[21] Zhu Y, Tang Q, Wang G, et al. Tanshinone IIA Protects Hippocampal Neuronal Cells from Reactive Oxygen Species Through Changes in Autophagy and Activation of Phosphatidylinositol 3-Kinase, Protein Kinas B, and Mechanistic Target of Rapamycin Pathways[J].Curr Neurovasc Res,2017 14 (2) : 132-140.
[22] Chen B H, Park J H, Cho JH, et al. Tanshinone I Enhances Neurogenesis in the Mouse Hippocampal Dentate Gyrus via Increasing Wnt-3, Phosphorylated Glycogen Synthase Kinase-3β and β-Catenin Immunoreactivities[J].Neurochem Res,2016 41 (8) : 1958-1968.
[23] Mirabelli-Badenier M, Braunersreuther V, Viviani GL, et al. CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke[J].Thromb Haemost,2011 105 (3) : 409-420.
[24] Liu B,Zhang Y,Jiang Y,et al. Electrical stimulation of cerebellar fastigial nucleus protects against cerebral ischemic injury by PPARγ upregulation[J].Neurol Res,2017 39 (1) : 23-29.
[25] 顾平. 丹参酮IIA磺酸钠注射液对老年缺血性脑卒中患者超敏C反应蛋白和白细胞介素-8水平的影响及疗效[J].中国老年学杂志,2012 32 (8) : 1674-1675.
入驻平台
回到首页
扫一扫，添加我们