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Open Access Article
International Journal of Clinical Research. 2021; 5: (1) ; 32-36 ; DOI: 10.12208/j.ijcr.20210008.
陕西中医药大学附属医院 陕西咸阳
*通讯作者: 刘力,单位:陕西中医药大学附属医院 陕西咸阳;
陕西省重点研发计划项目
发布时间: 2021-01-29 总浏览量: 2280
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随着炎症性肠病(inflammatory bowel disease, IBD)发病率的日益增长及近年来对人体微生物组学的密切关注和深入研究,肠道菌群与IBD发病间的关系受到广泛关注。炎症性肠病的切确病因和发病机制尚未完全阐明,但诸多实验已经证实肠道菌群的变化可能影响IBD的发生发展,通过调节菌群治疗IBD具有一定的积极作用,其中微生物制剂及中药的运用疗效较为可观,本文就微生态制剂、中药与IBD肠道菌群之间的关系作一综述。
With the increasing incidence of inflammatory bowel disease (IBD) and the close attention and in-depth study of human microbiome in recent years, the relationship between the intestinal flora and the incidence of IBD has received extensive attention. The exact etiology and pathogenesis of inflammatory bowel disease have not been fully elucidated, but many experiments have confirmed that changes in the intestinal flora may affect the occurrence and development of IBD. The treatment of IBD by regulating the flora has a certain positive effect. Among them, microbial preparations and Chinese medicines The therapeutic effect of the application of IBD is considerable. This article reviews the relationship between microecological preparations, traditional Chinese medicine and IBD intestinal flora.
[1] Ng Siew C,Shi Hai Yun,Hamidi Nima,et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.[J].Lancet,2018 390 (10114) : 2769-2778.
[2] Leake SL,Pagni M,Falquet L,et al. The salivary microbiome for differentiating individuals: proof of principle[J].Microbes Infection,2016 18 (6) : 399-405.
[3] Sheehan D, Moran C, Shanahan F. The microbiota in inflamma-tory bowel disease [J].J Gastroenterol,2015 50 (5) : 495-507.
[4] Olszak T, An D, Zeissig S, et al. Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function[J].Science,2012 336 (6080) : 489-493.
[5] Hammer HF. Gut microbiota and inflammatory bowel disease[J].Digestive Diseases,2011 29 (6) : 550.
[6] Rigottier-Gois L. Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis[J].ISME J,2013 7 (7) : 1256-1261.
[7] Linskens R K,Huijsdens X W,Savelkoul P H,et al. The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics[J].Scandinavian journal of gastroenterology. Supplement,2002 (234) : 292.
[8] Britton GJ, Contijoch EJ, Mogno I, et al. Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+Regulatory T Cells and Exacerbate Colitis in Mice.Immunity,2019 50 (1) : 212-224.
[9] He C, Wang H, Liao WD, et al. Characteristics of mucosa-associated gut microbiota during treatment in Crohn's disease.World J Gastroenterol,2019 25 (18) : 2204-2216.
[10] Lloyd-Price Jason,Arze Cesar, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases[J].Nature,2019 569 (7758) .
[11] Zhao L, Xiong Q, Stary CM, et al. Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke.J Neuroinflammation,2018 15 (1) : 339.
[12] Koh JH, Kim WU. Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity.Exp Mol Med,2017 49 (5) : 337.
[13] 涂晶. 益生菌联合美沙拉嗪治疗炎症性肠病的疗效探讨[J].全科口腔医学电子杂志,2019 6 (15) : 128-129.
[14] 王红. 美沙拉嗪与益生菌治疗炎症性肠病的临床疗效[J].航空航天医学杂志,2019 4 (30) : 398-399.
[15] 周洪美,刘秀珍,牟文芝,等. 益生菌联合柳氮磺胺吡啶灌肠治疗溃疡性结肠炎的临床观察[J].中华临床医师杂志,2010 4 (09) : 1671-1672.
[16] 陈娇娇,周莹群. 肠道菌群在炎症性肠病发病机制中作用的研究进展[J].世界临床药物,2019 40 (05) : 324-328.
[17] Valcheva R, Koleva P, Martínez I, et al. nulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels.Gut Microbes,2019 10 (3) : 334-357.
[18] 梁金花,郑科文,金大伟. 黄芪多糖对溃疡性结肠炎大鼠肠道菌群调节作用的研究[J].中国中医药科技,2012 19 (4) : 331-332.
[19] 梁金花,孙立群. 探讨中药黄芪多糖对溃疡性结肠炎大鼠肠道菌群失调的调整作用[J].微量元素与健康研究,2013 30 (2) : 1-3.
[20] 温如燕. 通过肠道菌群和Thl7/Treg细胞探讨大黄牡丹汤治疗炎症性肠病的作用机制[D].广州中医药大学,2016 .
[21] 陈珠. 砂仁对炎症性肠病大鼠的治疗作用及其初步机理研究[D].昆明:云南中医学院,2017 : 33-42.
[22] 屈畅. 广藿香醇抗炎症性肠病的代谢组学和肠道菌群分析研究[D].广州中医药大学,2018 .
[23] Burge K, Gunasekaran A, Eckert J, et al. Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection.Int J Mol Sci,2019 20 (8) : 1912.
[24] Pasternak Björn,Svanström Henrik,et al. Use of azathioprine and the risk of cancer in inflammatory bowel disease[J].American journal of epidemiology,2013 177 (11) .
[25] Lemaitre Magali, Kirchgesner Julien. Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With Inflammatory Bowel Disease[J].JAMA,2017 318 (17) : 1679-1686.
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