摘要
目的 探讨慢性鼻炎患者应用玉屏风散合四君子汤加减治疗的效果评价。方法 选择2024年5月-2025年5月期间接收的慢性鼻炎患者80例，采用随机数字表法将80例患者分成对照组（40例，采取常规西药治疗），和观察组（40例，在对照组治疗基础上应用玉屏风散合四君子汤加减治疗）。对两组的肿瘤坏死因子‑α（TNF-α）、NO指标水平、中医证候积分、临床疗效及疾病复发率进行对比和评估。结果 在治疗前，两组患者的TNF-α、NO指标水平、中医证候积分之间无明显区别（P>0.05）。治疗后，观察组TNF-α、NO指标水平显著低于对照组（P<0.05），中医证候积分低于对照组（P<0.05）；此外，观察组临床治疗总有效率高于对照组（P<0.05），疾病复发率低于对照组（P<0.05）。结论 玉屏风散合四君子汤加减治疗在慢性鼻炎患者应用中的作用效果显著，可有效改善TNF-α、NO指标水平、中医证候，降低疾病复发率，有较高应用价值。
关键词： 慢性鼻炎；玉屏风散；四君子汤加减治疗；复发率
Abstract
Objective Exploring the effectiveness evaluation of using Yupingfeng San combined with Sijunzi Tang for the treatment of chronic rhinitis patients with modifications. Methods 80 patients with chronic rhinitis who were admitted between May 2024 and May 2025 were selected. The 80 patients were randomly divided into a control group (40 cases, treated with conventional Western medicine) and an observation group (40 cases, treated with Yupingfeng San and Sijunzi Tang in addition to the control group) using a random number table method. Compare and evaluate the levels of TNF - α and NO indicators, TCM syndrome scores, clinical efficacy, and disease recurrence rate between the two groups. Results Before treatment, there was no significant difference in the levels of Tumor Necrosis Factor‑α (TNF‑α), NO indicators, and TCM syndrome scores between the two groups of patients (P>0.05). After treatment, the levels of TNF - α and NO indicators in the observation group were significantly lower than those in the control group (P<0.05), and the TCM syndrome score was lower than that in the control group (P<0.05); In addition, the total effective rate of clinical treatment in the observation group was higher than that in the control group (P<0.05), and the disease recurrence rate was lower than that in the control group (P<0.05). Conclusion The combination of Yupingfeng San and Sijunzi Tang with modifications has a significant therapeutic effect on patients with chronic rhinitis. It can effectively improve the levels of TNF - α and NO indicators, traditional Chinese medicine syndromes, reduce disease recurrence rates, and has high application value.
Key words： Chronic rhinitis; Yuping wind dispersing and merging; Four gentlemen’s soup with modifications for treatment; Recurrence rate
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