Correlation study between functional recovery of ischemic stroke patients and serum vitamin levels
缺血性脑卒中患者功能恢复与血清维生素水平的相关性研究

摘要

目的 研究缺血性脑卒中（AIS）患者功能恢复与血清维生素水平的相关性。方法 选择我院2023年5月-2025年6月纳入AIS患者共92例，分别在入院时、入院90d时测定血清维生素水平，并根据“改良Rankin量表（mRs）”评分结果，划分为科研组（mRs值≤2分为预后良好患者，n=52）、参照组（mRs值为3-5分为预后不良患者，n=40），分析AIS患者功能恢复与血清维生素水平的相关性。结果 入院时，两组比较血清维生素水平无差异，P>0.05；入院90d后，科研组血清维生素水平高于参照组；两组比较年龄、糖尿病病史、入院美国国立卫生研究院卒中量表（NIHSS）值、空腹血糖及同型半胱氨酸指标有统计学差异；科研组总维生素缺乏率低于参照组；经Logistic回归分析，引起患者90d功能恢复不良的独立危险因素有：入院NIHSS值、维生素D缺乏、维生素B12及叶酸缺乏，P<0.05。结论 维生素D、维生素B12及叶酸水平与AIS患者90d后功能恢复有关，其缺乏可独立预测恢复不良，临床需对上述维生素的监测高度重视，尽早补充。

Abstract

Objective To study the correlation between functional recovery of ischemic stroke (AIS) patients and serum vitamin levels.
Methods A total of 92 AIS patients were selected from our hospital from May 2023 to June 2025. Serum vitamin levels were measured at admission and 90 days after admission. According to the “modified Rankin Scale (mRs)” score results, they were divided into the research group (mRs value ≤ 2 was considered as patients with good prognosis, n = 52) and the reference group (mRs value was 3-5, considered as patients with poor prognosis, n = 40). The correlation between functional recovery of AIS patients and serum vitamin levels was analyzed.
Results At admission, there was no difference in serum vitamin levels between the two groups, P > 0.05. After 90 days of admission, the serum vitamin levels of the research group were higher than those of the reference group. There were statistically significant differences in age, history of diabetes, National Institutes of Health Stroke Scale (NIHSS) value at admission, fasting blood glucose, and homocysteine indicators between the two groups. The total vitamin deficiency rate of the research group was lower than that of the reference group. Logistic regression analysis showed that the independent risk factors for poor functional recovery of patients 90 days after admission were: NIHSS value at admission, vitamin D deficiency, vitamin B12 and folic acid deficiency, P < 0.05.
Conclusion   The levels of vitamin D, vitamin B12 and folic acid are related to the functional recovery of AIS patients 90 days after admission. Their deficiency can independently predict poor recovery. Clinically, it is necessary to attach great importance to the monitoring of these vitamins and supplement them as early as possible.