The study of AdipoRon on myocardial remodeling and cardiac function in transgenic mice with acute coronary syndrome
AdipoRon对转基因小鼠ACM心肌重构和心功能的研究

摘要

目的 探讨AdipoRon对转基因小鼠 ACM 心肌重构和心功能的研究。方法 4周龄的DSG2E11-K0ACM转基因小鼠各10只，分别应用AdipoRon和安慰剂灌胃4周。小鼠第8周时，运用心脏超声检测心功能水平，并从病理形态学评估AdipoRon对AIC的病理改变。结果 AdipoRon组左心室收缩末期内径、左心室舒张末期内径、左心室等容收缩期时间及左心室等容舒张期时间低于安慰剂组（P<0.05）；左心室射血分数、短轴缩短率及左心室射血期时间高于安慰剂组（P<0.05）；AdipoRon组小鼠心肌得到改善，纤维化减轻，且心肌萎缩得到缓解，炎症细胞浸润相对较少。结论 AdipoRon 能够改善转基因小鼠 ACM 心功能、减轻心肌病理改变，抑制心肌重构，为临床治疗提供新思路。

Abstract

Objective To investigate the effects of AdipoRon on myocardial remodeling and cardiac function in transgenic mice with acute coronary syndrome (ACM).
Methods Ten 4-week-old DSG2E11-K0ACM transgenic mice were administered AdipoRon or placebo by gavage for 4 weeks. At the 8th week, cardiac ultrasound was used to measure the cardiac function levels, and pathological morphology was used to evaluate the pathological changes of AdipoRon on ACM.
Results The left ventricular end-diastolic diameter, left ventricular end-systolic diameter, isovolumic contraction time, and isovolumic relaxation time in the AdipoRon group were lower than those in the placebo group (P < 0.05); the left ventricular ejection fraction, short-axis shortening rate, and left ventricular ejection period time were higher than those in the placebo group (P < 0.05); the myocardium of mice in the AdipoRon group improved, fibrosis was reduced, myocardial atrophy was alleviated, and inflammatory cell infiltration was relatively less.
Conclusion   AdipoRon can improve the cardiac function of transgenic mice with ACM, alleviate myocardial pathological changes, inhibit myocardial remodeling, and provide new ideas for clinical treatment.