Application value of individualized administration regimen of meropenem based on urinary drug concentration monitoring in patients with Pseudomonas aeruginosa pyelonephritis
基于尿药浓度监测的美罗培南个体化给药方案在铜绿假单胞菌肾盂肾炎患者中的应用价值

摘要

目的 本文分析使用尿药浓度监测制定的美罗培南个体化给药方案，该方案在铜绿假单胞菌肾盂肾炎患者中的临床应用价值。方法 本文将2024年11月至2026年2月期间医院收治的42例铜绿假单胞菌肾盂肾炎患者作为研究样本，运用随机数字表方法把它们分成观察组和对照组，各组均为21例。对照组采用美罗培南经验性给药方案，即1g每8小时静脉滴注，观察组根据尿药浓度监测结果制定个体化给药方案。本文对比两组患者的临床治疗效果、细菌学治疗结果、尿药浓度达到标准的比例。结果 观察组临床总有效率显著高于对照组，差异有统计学意义（P<0.05）；观察组细菌学疗效评价、尿药浓度%fT>MIC达标率显著高于对照组，差异有统计学意义（P<0.05）。结论 根据尿药浓度监测结果制定的美罗培南个体化给药方案可以明显改善铜绿假单胞菌肾盂肾炎患者的治疗效果，加快感染控制进程，基层医院应对此类方案进行推广和应用。

Abstract

Objective This article analyzes the individualized dosing regimen of meropenem developed using urine drug concentration monitoring, and its clinical application value in patients with Pseudomonas aeruginosa pyelonephritis.
Methods This study selected 42 patients with Pseudomonas aeruginosa pyelonephritis admitted to the hospital from November 2024 to February 2026 as the research sample. They were randomly divided into an observation group and a control group using a random number table method, with 21 patients in each group. The control group adopted an empirical dosing regimen of meropenem, which involved intravenous infusion of 1g every 8 hours. The observation group developed an individualized dosing regimen based on the monitoring results of urine drug concentration. This article compares the clinical treatment efficacy, bacteriological treatment results, and the proportion of urine drug concentration reaching the standard between two groups of patients.
Results The total clinical effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05); The bacteriological efficacy evaluation and urinary drug concentration% fT>MIC compliance rate of the observation group were significantly higher than those of the control group, and the difference was statistically significant (P<0.05).
Conclusion   The individualized administration plan of meropenem based on the monitoring results of urine drug concentration can significantly improve the treatment effect of patients with Pseudomonas aeruginosa pyelonephritis, accelerate the infection control process, and grassroots hospitals should promote and apply such plans.