Meta-analysis of the clinical effect of probiotics-assisted SRP in the treatment of chronic periodontitis
益生菌辅助SRP治疗慢性牙周炎临床效果的Meta分析

摘要

目的 系统评价益生菌辅助龈下刮治联合根面平整术（SRP）治疗慢性牙周炎的临床效果。方法 检索2020-2025年CNKI、PubMed等数据库，收集益生菌辅助SRP治疗慢性牙周炎的随机对照试验（RCT），经文献筛选、质量评价后，采用R软件进行Meta分析。结果 共纳入12项RCT（896例患者），试验组（SRP+益生菌）452例，对照组（单纯SRP）444例。Meta分析显示，试验组治疗后3个月、6个月的牙周袋深度（PPD）、牙龈指数（GI）、出血指数（BI）均显著低于对照组，临床附着水平（CAL）显著优于对照组（均P<0.05）。敏感性分析提示结果稳定，漏斗图提示存在轻微发表偏倚但不影响可靠性。结论 益生菌辅助SRP治疗慢性牙周炎临床效果优于单纯SRP，可显著改善牙周指标、减轻炎症。

Abstract

Objective To systematically evaluate the clinical effect of probiotics-assisted subgingival scaling and root planing (SRP) in the treatment of chronic periodontitis.
Methods Databases such as CNKI and PubMed were searched from 2020 to 2025 to collect randomized controlled trials (RCTs) on the treatment of chronic periodontitis with probiotics-assisted SRP. After literature screening and quality evaluation, a Meta-analysis was conducted using R software.
Results A total of 12 RCTs (896 patients) were included, with 452 patients in the experimental group (SRP + probiotics) and 444 patients in the control group (SRP alone). The Meta-analysis showed that the periodontal pocket depth (PPD), gingival index (GI), and bleeding index (BI) of the experimental group were significantly lower than those of the control group at 3 and 6 months after treatment, and the clinical attachment level (CAL) was significantly better than that of the control group (all P < 0.05). Sensitivity analysis indicated that the results were stable, and the funnel plot suggested a slight publication bias but did not affect the reliability.
Conclusion   Probiotics-assisted SRP has a better clinical effect in the treatment of chronic periodontitis than SRP alone, and can significantly improve periodontal indicators and reduce inflammation.