欢迎来到OAJRC平台！

核心 CSCIED

期刊栏目

投稿

审稿

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据：

当前位置：国际临床研究杂志 > 2026年 10卷 (5)期

Open Access Article

International Journal of Clinical Research. 2026; 10: (5) ; 34-38 ; DOI: 10.12208/j.ijcr.20260230.

Research progress on the application of neuron-specific enolase in pulmonary diseases
神经元特异性烯醇化酶（NSE）在肺部疾病中的应用研究进展

作者： 付瑶¹, 郎现亮², 于乐香¹, 李田华¹ *

1山东第二医科大学第一附属医院，潍坊市人民医院山东潍坊

2山东省临朐县第二人民医院山东临朐

*通讯作者：李田华,单位：山东第二医科大学第一附属医院，潍坊市人民医院山东潍坊；

潍坊市卫健委科研项目（项目编号：WFWSJK-2021-105）

发布时间: 2026-05-22 总浏览量: 41

PDF 全文下载引用本文

摘要

神经元特异性烯醇化酶（neuron-specific enolase, NSE）是神经元和神经内分泌细胞所特有的一种酸性蛋白酶，是判定脑损伤敏感的生化指标。近年来，NSE在肺部疾病中的应用越来越广泛，成为研究热点。在小细胞肺癌中，NSE作为神经内分泌标志物，诊断敏感性可达60%-80%；在肺结核中，NSE水平与疾病活动性相关，治疗前均值可达29.22ng/mL，治疗后显著下降（P<0.001）；在慢性阻塞性肺疾病中，NSE与炎症标志物CRP呈正相关（P<0.001），且随疾病严重程度升高；在间质性肺病如肺泡蛋白沉积症中，NSE与疾病严重程度指数LDH呈正相关（r=0.56，P<0.001）；在急性肺损伤动物模型中，NSE抑制剂可减轻肺损伤；在肺炎中，重症肺炎患儿NSE水平显著高于普通肺炎患儿（P<0.05）。NSE作为一种多功能蛋白，在肺部疾病尤其是在肺炎中的诊断、病情监测和预后评估中具有重要价值。本文系统综述了NSE在肺部疾病中的应用研究进展。

关键词： 神经元特异性烯醇化酶；肺部疾病；肺炎；综述

Abstract

Neuron-specific enolase (NSE) is an acidic protease unique to neurons and neuroendocrine cells, serving as a sensitive biochemical indicator for assessing brain injury. In recent years, the application of NSE in pulmonary diseases has become increasingly widespread, making it a research hotspot. In small cell lung cancer, NSE serves as a neuroendocrine biomarker with a diagnostic sensitivity of 60%-80%. In tuberculosis, NSE levels correlate with disease activity, with a pre-treatment mean of 29.22 ng/mL, which significantly decreases post-treatment (P<0.001). In COPD, NSE positively correlates with the inflammatory marker CRP (P<0.001) and increases with disease severity; In interstitial lung diseases such as pulmonary alveolar proteinosis, NSE shows a positive correlation with the disease severity index LDH (r=0.56, P<0.001). In acute lung injury animal models, NSE inhibitors can mitigate lung injury. In pneumonia, NSE levels in children with severe pneumonia are significantly higher than those in children with ordinary pneumonia (P<0.05). As a multifunctional protein, NSE holds significant value in the diagnosis, disease monitoring, and prognosis assessment of pulmonary diseases, particularly pneumonia. This article systematically reviews the research progress on the application of NSE in pulmonary diseases.

Key words： Neuron-specific enolase; Pulmonary disease; Pneumonia; Summarize

参考文献 References

[1] Hannaert V, Brinkmann H, Nowitzki U, et al. Enolase from Trypanosoma Brucei, from the amitochondriate protist Mastigamoeba Balamuthi, and from the chloroplast and cytosol of Euglena gracilis: pieces in the evolutionary puzzle of the eukaryotic glycolytic pathway[J]. Mol Biol Evol, 2000,17:989–1000.

[2] Cooper EH. Neuron-specific enolase. Int J Biol Markers, 1994 Oct-Dec,9(4):205-10.

[3] Christin S Kuo , Spyros Darmanis, Alex Diaz de Arce , et al. Neuroendocrinology of the lung revealed by single-cell RNA sequencing[J]. Elife, 2022, 11: e78216.

[4] Xu J, Yu H. Less is more: rare pulmonary neuroendocrine cells function as critical sensors in lung[J]. Dev Cell, 2020,55(2):123–32.

[5] Piast M, Kustrzeba-Wojcicka I, Matusiewicz M, et al. Molecular evolution of enolase[J]. Acta Biochim Pol, 2005, 52:507–513.

[6] Xu CM, Luo YL, Li S, et al. Multifunctional neuron-specific enolase: its role in lung diseases[J]. Biosci Rep, 2019,39(11):BSR20192732.

[7] Isgrò MA, Bottoni P. Neuron-specific enolase as a biomarker: biochemical and clinical aspects[J]. Adv Exp Med Biol, 2015,867:125–143.

[8] Ebert W, Muley T, Trainer C, et al. Comparison of changes in the NSE levels with clinical assessment in the therapy monitoring of patients with SCLC. Anticancer Res, 2002 Mar-Apr,22(2B):1083-9.

[9] Patricia Mjønes L, Sagatun IS, Nordrum, et al. Neuron-specific enolase as an immunohistochemical marker is better than its reputation[J]. Epub, 2017,65(12):687–703.

[10] Racil H, Saad S, Rouhou SC, et al. The value of tumor markers in pulmonary tuberculosis[J]. Tunis Med, 2009, 87:330–333.

[11] Zhang CX, Zhang DJ, Wang YL, et al. Expression level of NSE, S100B and NPY in children with acute miliary phthisis and secondary tubercular meningitis[J]. Eur. Rev. Med. Pharmacol. Sci, 2016,20: 1474–1478 .

[12] Rohlwink UK, Mauff K, Wilkinson KA, et al. Biomarkers of cerebral injury and inflammation in pediatric tuberculous meningitis[J]. Clin. Infect. Dis, 2017, 65:1298–1307.

[13] Nam SJ, Jeong JY, Jang TW, et al. Neuron-specifific enolase as a novel biomarker reflflecting tuberculosis activity and treatment response[J]. Korean J. Intern. Med, 2016,31: 694–702,

[14] Barouchos, N, Papazafifiropoulou, A, Iacovidou, N. et al. Comparison of tumor markers and inflflammatory biomarkers in chronic obstructive pulmonary disease (COPD) exacerbations[J]. Scand. J. Clin. Lab. Invest,2015, 75: 126–132,

[15] Li J, Kong X, Shu W, et al. The association of serum neuron-specific enolase with other disease markers in chronic obstructive pulmonary disease: a case control study[J]. Pak J Med Sci,2018,34(5):1172–1176.

[16] Sierra-Rivera A, Ferriz-Vivancos J, Fandos-Sánchez M, et al. Utility of anti-GM-CSF antibodies in the diagnosis of pulmonary alveolar proteinosis: a case report. EJIFCC, 2023 ,,34(2):174-180.

[17] Wołoszczak J, Wrześniewska M, Hrapkowicz A, et al. A Comprehensive Outlook on Pulmonary Alveolar Proteinosis-A Review. Int J Mol Sci, 2024 ,25(13):7092.

[18] Ludtke TH, Rudat C, Wojahn I, et al. Tbx2 and Tbx3 act downstream of shh to maintain canonical wnt signaling during branching morphogenesis of the murine lung[J]. Dev Cell, 2016, 39:239–253.

[19] Fang SC, Lu KH, Wang CY, et al. Elevated tumor markers in patients with pulmonary alveolar proteinosis[J]. Clin Chem Lab Med, 2013, 51:1493–1498.

[20] Arai T, Inoue Y, Sugimoto C, et al. CYFRA 21 – 1 as a disease severity marker for autoimmune pulmonary alveolar proteinosis[J]. Respirology, 2014,19:246–252.

[21] Zhao YX, Dong ZP, Fan ZM, et al. Changes of neuron specific enolase in serum of patients with silicosis. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2021,39(3):215–217.

[22] Gong Y, Lan H, Yu Z, et al. Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells[J]. Biochem Biophys Res Commun, 2017,491:522–529

[23] Zhong WJ, Yang HH, Guan XX, et al. Inhibition of glycolysis alleviates lipo-polysaccharide-induced acute lung injury in a mouse model[J]. J Cell Physiol, 2019,234:4641–41654.

[24] Cui H, Li S, Xu, C, et al. Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis[J]. Mol. Med. Rep, 2017,16:5121–5128,

[25] Guice, K S, Oldham K T, Johnson K J , et al. Pancreatitis-induced acute lung injury[J]. An ARDS model.Ann. Surg, 1988, 208:71–77.

[26] Owusu L, Xu C, Chen H, et al. Gamma-enolase predicts lung damage in severe acute pancreatitis-induced acute lung injury[J]. J. Mol. Histol, 2018, 49:347–356.

[27] Erika C, Antonio S, Pietro G, et al. Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury[J]. PLoS ONE, 2021,16(5):e0251819.

[28] Denise Battaglini HC, Castro-Faria-Neto, et al. Laboratory biomarkers for diagnosis and prognosis in COVID-19[J]. Front Immunol, 2022,13:857573.

[29] Tianhua L, Minglei L, Jie F, et al. Evaluation and clinical significance of serum neurospecific enolase in children with pneumonia: a case-control study[J]. BMC Pediatr, 2024, 24(1):379.

[30] Jinhao Xu , Haoze Yu , Xin Sun .Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung[J].Dev Cell, 2020 ,55(2):123-132.

引用本文

付瑶, 郎现亮, 于乐香, 李田华, 神经元特异性烯醇化酶（NSE）在肺部疾病中的应用研究进展[J]. 国际临床研究杂志, 2026; 10: (5) : 34-38.

入驻平台

回到顶部

搜索文章: