参考文献 References
[1] 张洁.24 小时动态血压变异性和 β2 微球蛋白与缺血性卒中患者血管周围间隙扩大的相关性研究 [D]. 蚌埠：蚌埠医学院，2022.
[2] Albrecht U, Eichele G. The mammalian circadian clock [J]. Current Opinion in Genetics & Development, 2003,13 (3):271-277.
[3] 陈梦月，陈苗，傅舒凝，等。血压的生物钟调节 [J]. 科学通报，2025,70 (21):3398-3405.
[4] Weaver D R. The suprachiasmatic nucleus: a 25-year retrospective [J]. Journal of Biological Rhythms,1998,13 (2):100-112.
[5] Schibler U, Gotic I, Saini C, et al. Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals [J]. Cold Spring Harbor Symposia on Quantitative Biology,2015,80:223-232.
[6] Nagoshi E, Saini C, Bauer C, et al. Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells [J]. Cell,2004,119 (5):693-705.
[7] Carrasco-Benso M P, Rivero-Gutierrez B, Lopez-Minguez J, et al. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity [J]. The FASEB Journal, 2016,30 (9):3117-3123.
[8] Mastrullo V, van der Veen D R, Gupta P, et al. Pericytes' Circadian Clock Affects Endothelial Cells' Synchronization and Angiogenesis in a 3D Tissue Engineered Scaffold [J]. Frontiers in Pharmacology,2022,13:867070.
[9] Takahashi J S. Transcriptional architecture of the mammalian circadian clock [J]. Nature Reviews Genetics, 2017,18 (3):164-179.
[10] Xin M, Bi F, Wang C, et al. The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system [J]. Journal of Advanced Research, 2025,69:495-514.
[11] Costello H M, Gumz M L. Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension [J]. Hypertension,2021,78 (5):1185-1196.
[12] Chellappa S L, Vujovic N, Williams J S, et al. Impact of Circadian Disruption on Cardiovascular Function and Disease [J]. Trends in Endocrinology & Metabolism, 2019,30 (10):767-779.
[13] Peschke E, Bach A G, Mühlbauer E. Parallel signaling pathways of melatonin in the pancreatic beta-cell [J]. Journal of Pineal Research,2006,40 (2):184-191.
[14] Xie M, Tang Q, Nie J, et al. BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atheros-clerosis by Encouraging Oxidative Stress [J]. Circulation Research, 2020,126 (6):e15-e29.
[15] Niu L, Zhang F, Xu X, et al. Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology [J]. Brain Pathology,2022,32 (3):e13028.
[16] Jokl E, Llewellyn J, Simpson K, et al. Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease [J]. Cells,2023,12 (12):1582.
[17] Jiang S, Li H, Zhang L, et al. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics [J]. Nucleic Acids Research,2025,53 (D1):D1670-D1676.
[18] 陈奕如，王浩哲，沈琦，等。心血管中枢在维持血压昼夜节律中的作用和机制研究进展 [J]. 生理科学进展，2026,57 (1):1-9.
[19] Curtis A M, Cheng Y, Kapoor S, et al. Circadian variation of blood pressure and the vascular response to asynchronous stress [J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (9):3450-3455.
[20] Xie Z, Su W, Liu S, et al. Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation [J]. The Journal of Clinical Investigation,2015,125 (1):324-336.
[21] Solocinski K, Holzworth M, Wen X, et al. Desoxycortico-sterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice [J]. Acta Physiologica, 2017,220 (1):72-82.
[22] Sei H, Oishi K, Chikahisa S, et al. Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice [J]. Endocrinology, 2008,149 (7):3576-3580.
[23] Chang L, Xiong W, Zhao X, et al. Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen [J]. Circulation,2018,138 (1):67-79.
[24] Tanaka S, Ueno T, Tsunemi A, et al. The adrenal gland circadian clock exhibits a distinct phase advance in spontaneously hypertensive rats [J]. Hypertension Research, 2019,42 (2):165-173.
[25] Doi M, Takahashi Y, Komatsu R, et al. Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6 [J]. Nature Medicine,2010,16 (1):67-74.
[26] Zhang D, Jin C, Obi I E, et al. Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice [J]. American Journal of Physiology-Renal Physiology,2020,318 (3):F710-F719.
[27] Crislip G R, Douma L G, Masten S H, et al. Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice [J]. American Journal of Physiology-Renal Physiology,2020,318 (6): F1463-F1477.
[28] Murata Y, Ueno T, Tanaka S, et al. Identification of Clock Genes Related to Hypertension in Kidney From Spontaneously Hypertensive Rats [J]. American Journal of Hypertension,2020,33 (12):1136-1145.
[29] 华琦，范利，李静，等。老年人异常血压波动临床诊疗中国专家共识 [J]. 中国心血管杂志，2017,22 (1):1-11.
[30] Feng Y, Lin H, Tan H, et al. Heterogeneity of aging and mortality risk among individuals with hypertension: Insights from phenotypic age and phenotypic age acceleration [J]. Journal of Nutrition, Health & Aging, 2024,28 (5):100203.
[31] 原慧萍，杨泽。氧化应激与衰老研究进展 [J]. 中国老年保健医学，2015,13 (5):14-17.
[32] 陈泽昊。高血压的发病原因和机制 [J]. 家庭生活指南，2025,41 (9):52-53.
[33] Singh A, Schurman S H, Bektas A, et al. Aging and Inflammation [J]. Cold Spring Harbor Perspectives in Medicine,2024,14 (6):a041197.
[34] Schrader L A, Ronnekleiv-Kelly S M, Hogenesch J B, et al. Circadian disruption, clock genes, and metabolic health [J]. The Journal of Clinical Investigation, 2024, 134 (14): e170998.
[35] Altamirano F G, Castro-Pascual I C, Ferramola M L, et al. Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure [J]. Biogerontology, 2021,22 (6):603-621.
[36] Semenovykh K, Pravenec M, Vaněčková I, et al. Tert Deletion Impairs Circadian Regulation of Blood Pressure in Male Spontaneously Hypertensive Rats [J]. Hypertension, 2026,83 (2):e25510.
[37] Richards J, Gumz M L. Mechanism of the circadian clock in physiology [J]. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013, 304 (12): R1053-R1064.
[38] Munakata M, Kameyama J, Kanazawa M, et al. Circadian blood pressure rhythm in patients with higher and lower spinal cord injury: simultaneous evaluation of autonomic nervous activity and physical activity [J]. Journal of Hypertension,1997,15 (12 Pt 2):1745-1749.
[39] Hou T, Chacon A N, Su W, et al. Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration [J]. Frontiers in Nutrition,2022,9:969345.
[40] Behuliak M, Bencze M, Boroš A, et al. Chronic inhibition of angiotensin converting enzyme lowers blood pressure in spontaneously hypertensive rats by attenuation of sympathetic tone: The role of enhanced baroreflex sensitivity [J]. Biomedicine & Pharmacotherapy, 2024, 176:116796.
[41] Calhoun D A, Harding S M. Sleep and hypertension [J]. Chest,2010,138 (2):434-443.
[42] Gangwisch J E. A review of evidence for the link between sleep duration and hypertension [J]. American Journal of Hypertension,2014,27 (10):1235-1242.
[43] Jarrin D C, Ivers H, Lamy M, et al. Cardiovascular autonomic dysfunction in insomnia patients with objective short sleep duration [J]. Journal of Sleep Research,2018,27 (3): e12663.
[44] Sherwood A, Routledge F S, Wohlgemuth W K, et al. Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity [J]. American Journal of Hypertension,2011,24 (9):982-988.
[45] Mancia G, Grassi G. The autonomic nervous system and hypertension [J]. Circulation Research,2014,114 (11):1804-1814.
[46] Spiegel K, Tasali E, Penev P, et al. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite [J]. Annals of Internal Medicine,2004,141 (11):846-850.
[47] Nagarajan P, Winkler T W, Bentley A R, et al. A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations [J]. Molecular Psychiatry,2025,30 (8):3660-3672.
[48] Ramos A R, Weng J, Wallace D M, et al. Sleep Patterns and Hypertension Using Actigraphy in the Hispanic Community Health Study/Study of Latinos [J]. Chest, 2018, 153 (1):87-93.
[49] 中国高血压防治指南修订委员会，高血压联盟 (中国), 中国医疗保健国际交流促进会高血压病学分会，等。中国高血压防治指南 (2024 年修订版)[J]. 中华高血压杂志 (中英文),2024,32 (7):603-700.
[50] Ibarz-Blanch N, Morales D, Calvo E, et al. Role of Chrononutrition in the Antihypertensive Effects of Natural Bioactive Compounds [J]. Nutrients,2022,14 (9):1920.
[51] Shanks J, Ramchandra R. Angiotensin II and the Cardiac Parasympathetic Nervous System in Hypertension [J]. International Journal of Molecular Sciences,2021,22 (22):12305.
[52] Parati G, Pengo M F, Avolio A, et al. Nocturnal blood pressure: pathophysiology, measurement and clinical implications. Position paper of the European Society of Hypertension [J]. Journal of Hypertension,2025,43 (8):1296-1318.
[53] Tobeiha M, Jafari A, Fadaei S, et al. Evidence for the Benefits of Melatonin in Cardiovascular Disease [J]. Frontiers in Cardiovascular Medicine,2022,9:888319.
[54] Makarem N, Shechter A, Carnethon M R, et al. Sleep Duration and Blood Pressure: Recent Advances and Future Directions [J]. Current Hypertension Reports,2019,21 (5):33.
[55] Fu X, Ren H, Xie J, et al. Association of Nighttime Masked Uncontrolled Hypertension With Left Ventricular Hypertrophy and Kidney Function Among Patients with Chronic Kidney Disease Not Receiving Dialysis [J]. JAMA Network Open,2022,5 (5):e2214460.