摘要
目的 分析真武汤治疗阳虚水泛证慢性心力衰竭对中医症候积分及左室射血分数、氨基末端脑利钠肽前体（NT-proBNP）的影响。方法 将2021年10月-2022年10月接收的78例阳虚水泛证慢性心力衰竭患者纳入研究，根据治疗方法分为参考组（常规治疗，n=39）与研究组（在常规治疗基础上增加真武汤，n=39）。对比两组治疗前后的心功能指标、中医症候积分、日常生活能力及不良反应。结果 治疗后，研究组的中医证候积分、NT-proBNP低于参考组，左室射血分数、日常生活能力评分高于参考组（P＜0.05）。研究组不良反应出现率与参考组无统计学意义（P＞0.05）。结论 针对阳虚水泛证慢性心力衰竭患者，实施真武汤治疗能改善心功能，减轻中医临床症候，提高日常生活能力，且不良反应少。
关键词： 阳虚水泛证慢性心力衰竭；真武汤；心功能
Abstract
Objective To analyze the effects of Zhenwu Decoction on the TCM syndrome score, left ventricular ejection fraction, and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the treatment of chronic heart failure with Yang deficiency and water retention syndrome. Methods A total of 78 patients with chronic heart failure due to Yang deficiency and water retention syndrome who were received from October 2021 to October 2022 were included in the study. They were divided into the reference group (general treatment, n=39) and the study group (with Zhenwu Decoction added on the basis of general treatment, n=39) according to the treatment methods. The cardiac function indicators, TCM syndrome scores, activities of daily living and adverse reactions before and after treatment were compared between the two groups. Results After treatment, the TCM syndrome score and NT-proBNP of the study group were lower than those of the reference group, while the left ventricular ejection fraction and activities of daily living score were higher than those of the reference group (P < 0.05). The occurrence rate of adverse reactions in the study group was not statistically significant compared with that in the reference group (P > 0.05). Conclusion For patients with chronic heart failure due to Yang deficiency and water retention syndrome, the implementation of Zhenwu Decoction treatment can improve cardiac function, alleviate clinical symptoms of traditional Chinese medicine, enhance the ability to perform daily activities, and has few adverse reactions.
Key words： Syndrome of yang deficiency with water flooding in chronic heart failure; Zhenwu Decoction; Cardiac function
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