Clinical efficacy of modified Taohe Chengqi Tang combined with low-dose mannitol in the treatment of acute cerebral edema in hypertensive intracerebral hemorrhage and its effects on C-reactive protein and procalcitonin
桃核承气汤加减联合低剂量甘露醇治疗高血压性脑出血急性期脑水肿的临床效果及对C反应蛋白、降钙素原的影响

摘要

目的 观察在对高血压性脑出血急性期脑水肿患者治疗过程中开展桃核承气汤加减联合低剂量甘露醇治疗的效果以及对患者C反应蛋白、降钙素原水平的影响。方法 前瞻性纳入2024年6月至2025年12月高血压性脑出血急性期脑水肿患者80例，数字表随机抽样均分2组，对照组（40例）进行常规治疗+低剂量甘露醇治疗，观察组（40例）需在对照组治疗基础上使用桃核承气汤加减治疗。对两组患者脑水肿吸收情况、神经功能改善情况、C反应蛋白、降钙素原水平进行观察。结果 脑水肿吸收情况，观察组吸收率高于对照组，（P<0.05）。NIHSS评分，观察组治疗后低于对照组，GCS评分观察组治疗后高于对照组，（P<0.05）。C反应蛋白、降钙素原水平，观察组治疗后低于对照组，（P<0.05）。结论 在对高血压性脑出血急性期脑水肿患者治疗过程中开展桃核承气汤加减联合低剂量甘露醇治疗，有助于提升患者脑水肿吸收率，促进患者受损神经功能恢复，降低患者C反应蛋白水平、降钙素原水平，有助于患者恢复。

Abstract

Objective To observe the effect of modified Taohe Chengqi Decoction combined with low-dose mannitol on the treatment of acute cerebral edema in patients with hypertensive intracerebral hemorrhage, and its impact on the levels of C-reactive protein and procalcitonin in patients.
Methods A prospective study was conducted on 80 patients with acute phase cerebral edema of hypertensive intracerebral hemorrhage from June 2024 to December 2025. The patients were randomly divided into two groups using a digital table. The control group (40 cases) received conventional treatment plus low-dose mannitol treatment, while the observation group (40 cases) received modified Taohe Chengqi Decoction on the basis of treatment in the control group. Observe the absorption of cerebral edema, improvement of neurological function, C-reactive protein, and procalcitonin levels in two groups of patients.
Results The absorption rate of cerebral edema in the observation group was higher than that in the control group, (P<0.05). The NIHSS score in the observation group was lower than that in the control group after treatment, and the GCS score in the observation group was higher than that in the control group after treatment, (P<0.05). The levels of C-reactive protein and procalcitonin in the observation group were lower than those in the control group after treatment, (P<0.05).
Conclusion   In the treatment of acute cerebral edema in patients with hypertensive intracerebral hemorrhage, the combination of modified Taohe Chengqi decoction and low-dose mannitol can help improve the absorption rate of cerebral edema, promote the recovery of damaged nerve function, reduce the levels of C-reactive protein and procalcitonin, and facilitate the recovery of patients.