摘要
目的 观察对支气管扩张患者开展支气管舒张剂及吸入激素治疗的效果以及安全性。方法 前瞻性纳入2024年4月至2025年8月支气管扩张患者76例,数字表随机抽样均分2组,对照组(38例)进行常规治疗,观察组(38例)进行支气管舒张剂及吸入激素治疗。对患者肺功能、症状改善用时以及不良反应进行统计。结果 肺功能水平,观察组治疗后高于对照组,(P<0.05)。症状改善用时,观察组短于对照组,(P<0.05)。不良反应发生率,观察组与对照组无明显差异,(P>0.05)。结论 对支气管扩张患者进行支气管舒张剂及吸入激素治疗,有助于改善患者各方面症状,促进患者肺功能进行恢复,且不会增加患者治疗期间不良反应发生率,可以保障治疗过程中的安全性。
关键词: 支气管舒张剂;吸入激素;支气管扩张;安全性
Abstract
Objective To observe the efficacy and safety of bronchodilators and inhaled steroids in the treatment of patients with bronchiectasis. Methods A prospective study was conducted on 76 patients with bronchiectasis from April 2024 to August 2025. The patients were randomly divided into two groups using a digital table. The control group (38 cases) received conventional treatment, while the observation group (38 cases) received bronchodilators and inhaled steroids. Statistical analysis of patients' lung function, symptom improvement time, and adverse reactions. Results The lung function level in the observation group was higher than that in the control group after treatment, (P<0.05). The improvement time of symptoms in the observation group was shorter than that in the control group, (P<0.05). The incidence of adverse reactions showed no significant difference between the observation group and the control group, (P>0.05). Conclusion Treatment with bronchodilators and inhaled steroids for patients with bronchiectasis can improve various symptoms, promote the recovery of lung function, and does not increase the incidence of adverse reactions during treatment, ensuring the safety of the treatment process.
Key words: Bronchodilators; Inhalation of hormones; Bronchiectasia; Safety
参考文献 References
[1] 沈红霞,邱振涛,马海兴,等. 脉冲振荡在支气管哮喘儿童中喘息症状的应用临床效果研究 [J]. 宁夏医学杂志, 2024, 46 (01): 72-74.
[2] 李蓓蕾,吕雄胜,李媛媛. 长效支气管舒张剂治疗组合方案开始时间对慢性阻塞性肺疾病急性加重的影响 [J]. 中国药物与临床, 2023, 23 (07): 436-440.
[3] 王小龙,伍英,李培根,等. 高渗盐水联合支气管舒张剂及乙酰半胱氨酸续贯雾化对支气管扩张症患者的疗效研究 [J]. 北方药学, 2023, 20 (06): 73-75.
[4] 张坤. 支气管舒张剂联合吸入激素治疗支气管扩张对患者症状的改善研究 [J]. 智慧健康, 2023, 9 (12): 70-73+77.
[5] 张佩海. 支气管舒张剂联合抗胆碱药治疗慢性阻塞性肺疾病的临床效果 [J]. 中国医药指南, 2023, 21 (11): 57-60.
[6] 邱鸣磊,余苗,徐丹. 支气管舒张剂联合糖皮质激素辅以黏液溶解剂治疗慢性阻塞性肺疾病急性加重期患者的疗效 [J]. 当代医学, 2022, 28 (19): 84-86.
[7] 王宝,黄伟杰,李丽珍,等. 支气管舒张剂联合抗胆碱药治疗老年慢性阻塞性肺疾病的临床疗效及安全性评价 [J]. 当代医学, 2022, 28 (15): 50-53.
[8] 罗小平. 支气管舒张剂联合吸入激素治疗支气管扩张的疗效及对患者肺功能的影响 [J]. 临床合理用药杂志, 2022, 15 (13): 63-65.
[9] 许银姬,金蕊,佟金平. 双联支气管舒张剂联合三子止咳胶囊治疗稳定期COPD的临床效果观察 [J]. 保健医学研究与实践, 2022, 19 (03): 15-18.
[10] 于洪英. 入院24 h内采用长效支气管舒张剂治疗慢性阻塞性肺疾病急性加重期的临床观察 [J]. 新疆医学, 2021, 51 (08): 924-927.