Study on the correlation between specific IgE antibody testing in children in the Ningxia region and allergic diseases
宁夏地区儿童特异性IgE抗体检测与过敏性疾病的相关性研究

摘要

目的 探讨宁夏地区儿童特异性IgE（sIgE）抗体阳性分布特征及其与过敏性疾病的相关性。方法 选取2025年1月-2025年12月就诊的疑似过敏性疾病患儿862例为研究对象，采用免疫印迹法检测总IgE及20种过敏原sIgE抗体，统计不同变量下的阳性率并分析关联性。结果 患儿sIgE抗体总阳性率为68.45%，过敏性鼻炎阳性率最高，吸入性过敏原阳性率高于食物性，10~14岁年龄段阳性率最高，性别差异无统计学意义；sIgE抗体阳性与疾病发生及严重程度均呈正相关。结论 宁夏地区儿童过敏性疾病与sIgE抗体阳性密切相关，该检测对疾病诊疗与防控具有重要指导价值。

Abstract

Objective To investigate the distribution characteristics of specific IgE (sIgE) antibodies in children in Ningxia region and their correlation with allergic diseases.
Methods A total of 862 children with suspected allergic diseases who visited the hospital from January 2025 to December 2025 were selected as the research subjects. Total IgE and 20 types of allergen sIgE antibodies were detected by immunoblotting. The positive rates under different variables were statistically analyzed and their correlations were investigated.
Results The total positive rate of sIgE antibodies in children was 68.45%. The positive rate of allergic rhinitis was the highest, and the positive rate of inhalant allergens was higher than that of food allergens. The positive rate was the highest in the 10-14 age group, and there was no statistical significance in gender differences. The positive sIgE antibodies were positively correlated with the occurrence and severity of the disease.
Conclusion   Allergic diseases in children in Ningxia region are closely related to positive sIgE antibodies. This detection has important guiding value for disease diagnosis, treatment and prevention.