欢迎来到OAJRC平台！

核心 CSCIED

期刊栏目

投稿

审稿

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据：

当前位置：国际临床研究杂志 > 2026年 10卷 (7)期

Open Access Article

International Journal of Clinical Research. 2026; 10: (7) ; 22-27 ; DOI: 10.12208/j.ijcr.20260325.

Household ozone inhalation inducing acute respiratory distress syndrome: A case report
家用臭氧中毒致急性呼吸窘迫综合征：西维来司他钠和肺保护策略成功治疗1例

作者： 林锐航¹, 乔博洋^1# , 刘国华^3# , 朝鲁孟², 刘云³, 肖斌¹ *

1 鄂尔多斯市中心医院中心实验室内蒙古鄂尔多斯;

2 鄂尔多斯市中心医院呼吸与危重症医学科内蒙古鄂尔多斯;

3 鄂尔多斯市中心医院重症医学科内蒙古鄂尔多斯;

*通讯作者：肖斌,单位：鄂尔多斯市中心医院中心实验室内蒙古鄂尔多斯；

内蒙古“英才兴蒙”工程青年拔尖人才资助项目（项目编号：内人才发[2024]3号）

发布时间: 2026-07-16 总浏览量: 28

PDF 全文下载引用本文

摘要

目的探讨家庭臭氧吸入致急性呼吸窘迫综合征（acute respiratory distress syndrome, ARDS）的临床特征及救治要点，评估其治疗策略的有效性。方法回顾性总结1例因等离子燃气灶故障吸入臭氧后发生重度ARDS患者的诊疗过程，详细分析其发病诱因、临床表现、影像学特点、鉴别诊断和治疗方法。结果经鼻高流量氧疗、糖皮质激素基础上，于病程第3天加用中性粒细胞弹性蛋白酶抑制剂西维来司他钠。治疗后炎症指标迅速下降，氧合及影像学显著改善，患者康复出院，干预手段及时、有效且符合当前临床指南推荐标准。结论家庭臭氧吸入可致严重ARDS，易被忽视。早期识别、综合支持并靶向抑制中性粒细胞介导的损伤是救治关键。本例为类似中毒事件提供了诊疗借鉴。

关键词： 化学性肺炎；臭氧；西维来司他钠；ARDS；中毒

Abstract

Objective To investigate the clinical characteristics and key treatment strategies for acute respiratory distress syndrome (ARDS) induced by household ozone inhalation, and to evaluate the effectiveness of the therapeutic approach.
Methods A retrospective analysis was conducted on the diagnosis and treatment process of a patient with severe ARDS caused by ozone inhalation due to a malfunctioning plasma gas stove. The study detailed the triggers, clinical manifestations, imaging characteristics, differential diagnosis, and treatment methods.
Results Based on high-flow nasal cannula oxygen therapy and corticosteroids, the neutrophil elastase inhibitor sivelestat sodium was added on day 3 of the clinical course. Following treatment, inflammatory markers decreased rapidly, and both oxygenation and imaging findings improved significantly. The patient recovered and was discharged. The interventions were timely and effective, aligning with current clinical guideline recommendations.
Conclusion Household ozone inhalation can lead to severe ARDS, which is often overlooked. Early detection, comprehensive supportive care, and targeted inhibition of neutrophil-mediated injury are critical for successful treatment. This case provides a reference for the diagnosis and management of similar poisoning incidents.

Key words： Chemical pneumonitis; Ozone; Sivelestat sodium poisoning; Acute respiratory distress syndrome; Poisoning

参考文献 References

[1] Bocci V, Borrelli E, Travagli V,et al. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev. 2009 Jul;29(4):646-682.

[2] Nogueira Leite N, Garcia Sperandio V, da Piedade Edmundo Sitoe E,et al. Ozone as a promising method for controlling Pseudomonas spp. biofilm in the food industry: a systematic review. Biofouling. 2024 Nov;40(10):660-678.

[3] Reidy E, Bottorff BP, Rosales CMF,et al. Measurements of Hydroxyl Radical Concentrations during Indoor Cooking Events: Evidence of an Unmeasured Photolytic Source of Radicals. Environ Sci Technol. 2023 Jan 17;57(2):896-908.

[4] Qian J, Liu KJ, Zhong CH,et al. Sivelestat sodium alleviated sepsis-induced acute lung injury by inhibiting TGF-β/Smad signaling pathways through upregulating microRNA-744-5p. J Thorac Dis. 2024 Oct 31;16(10):6616-6633.

[5] Zhang X, Li Z, Lei X,et al. Effect of sivelestat sodium on the incidence of ventilator-associated pneumonia in patients with sepsis and ARDS. Front Med (Lausanne). 2025 Aug 6;10:1618914.

[6] Wu T, Wang T, Jiang J,et al. Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) on Oxygenation in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome. J Inflamm Res. 2025 Mar 27;18:4449-4458.

[7] Matthay MA, Arabi Y, Arroliga AC,et al.. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024 Jan 1;209(1):37-47.

[8] Bergmann F, Pracher L, Sawodny R,et al. Efficacy and Safety of Corticosteroid Therapy for Community-Acquired Pneumonia: A Meta-Analysis and Meta-Regression of Randomized, Controlled Trials. Clin Infect Dis. 2023 Dec 15;77(12):1704-1713.

[9] Haan BJ, Blackmon SN, Cobb AM,et al. Corticosteroids in critically ill patients: A narrative review. Pharmacotherapy. 2024 Jul;44(7):581-602.

[10] Ocampo-Gallego JS, Pedroza-Escobar D, Caicedo-Ortega AR,et al. Human neutrophil elastase inhibitors: Classification, biological-synthetic sources and their relevance in related diseases. Fundam Clin Pharmacol. 2024 Feb;38(1):13-32.

[11] Zeng W, Song Y, Wang R,et al. Neutrophil elastase: From mechanisms to therapeutic potential. J Pharm Anal. 2023 Apr;13(4):355-366.

[12] Maio S, Fasola S, Marcon A,et al. Relationship of long-term air pollution exposure with chronic obstructive pulmonary disease: an Italian multicentre observational study. Occup Environ Med. 2025 Mar 4;82(1):21-27.

[13] Serra MEG, Baeza-Noci J, Mendes Abdala CV,et al. The role of ozone treatment as integrative medicine. An evidence and gap map. Front Public Health. 2023 Jan 16;10:1112296.

[14] 冯婷婷,王彬茹,柯维,等.急性臭氧中毒致意识障碍1例并文献复习[J].重庆医学,2021,50(01):172-174.

[15] Cheminant JR, Deering-Rice CE, Massa CB,et al. Parenchymal and inflammatory responses to ozone exposure in the aging healthy and surfactant protein C mutant lung. Am J Physiol Lung Cell Mol Physiol. 2025 Mar 1;328(3):L334-L349.

[16] Mehraban F, Seyedarabi A. Molecular effects of ozone on amino acids and proteins, especially human hemoglobin and albumin, and the need to personalize ozone concentration in major ozone autohemotherapy. Crit Rev Clin Lab Sci. 2023 Aug;60(5):382-397.

[17] Bahceci Erdem S, Nacaroglu HT, Isgüder R, Unsal Karkiner CS, Alper H, Can D. Pulmonary complications of chemical pneumonía: a case report. Arch Argent Pediatr. 2016 Aug 1;114(4):e245-8. English, Spanish.

[18] Bergmann F, Pracher L, Sawodny R,et al. Efficacy and Safety of Corticosteroid Therapy for Community-Acquired Pneumonia: A Meta-Analysis and Meta-Regression of Randomized, Controlled Trials. Clin Infect Dis. 2023 Dec 15;77(12):1704-1713.

[19] Haan BJ, Blackmon SN, Cobb AM,et al. Corticosteroids in critically ill patients: A narrative review. Pharmacotherapy. 2024 Jul;44(7):581-602.

[20] Auger JP, Zimmermann M, Faas M,et al. Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. 2024 May;629(8010):184-192.

[21] Oray M, Abu Samra K, Ebrahimiadib N,et al. Long-term side effects of glucocorticoids. Expert Opin Drug Saf. 2016;15(4):457-465.

[22] 孙同文,张西京,黎毅敏,等.中国成人急性呼吸窘迫综合征（ARDS）诊断与非机械通气治疗指南（2023）[J].中国研究型医院,2023,10(05):9-24.

[23] Zhang H, Zeng J, Li J,et al. Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways. Biomol Biomed. 2023 May 1;23(3):457-470.

[24] 静亮,彭希,祝伟.西维来司他钠治疗硝酸和氢氟酸吸入致急性呼吸窘迫综合征1例并文献复习[J].华中科技大学学报(医学版),2022,51(04):553-555.

[25] Jing L, Peng X, Li D,et al. Treatment with sivelestat sodium of acute respiratory distress syndrome induced by chemical pneumonitis: A report of three cases. Exp Ther Med. 2023 Aug 22;26(4):476.

引用本文

林锐航, 乔博洋#, 刘国华#, 朝鲁孟, 刘云, 肖斌, 家用臭氧中毒致急性呼吸窘迫综合征：西维来司他钠和肺保护策略成功治疗1例[J]. 国际临床研究杂志, 2026; 10: (7) : 22-27.

入驻平台

回到顶部

搜索文章: