摘要
目的 讨论及研究小剂量非布司他及苯溴马隆治疗肾排泄减少型男性痛风患者的疗效以及患者肝功能影响的短期研究。方法 参与本次研究患者的数量为100例，时间为2024年1月份至2024年12月份，通过随机分组分成对照组和实验组，每组50例患者，对照组小剂量非布司他，实验组为小剂量苯溴马隆，对比两组患者的治疗效果，以及对肝功能的影响。结果 治疗后，实验组患者的治疗效果优于对照组，p<0.05，对比肝功能指标，实验组优于对照组，p<0.05。结论 为肾排泄减少型男性痛风患者选择小剂量苯溴马隆治疗，可以提升患者的治疗效果，对患者的肝功能造成影响更小，值得提倡。
关键词： 小剂量非布司他；苯溴马隆；肾排泄减少型男性痛风；肝功能
Abstract
Objective To investigate the efficacy of low-dose febuxostat and benzbromarone in treating male gout patients with reduced renal excretion, along with short-term studies on their impact on liver function. Methods A total of 100 male gout patients were enrolled from January to December 2024. They were randomly divided into a control group (50 patients) receiving low-dose febuxostat and an experimental group (50 patients) receiving low-dose benzbromarone. The treatment outcomes and liver function effects were compared between the two groups. Results Post-treatment, the experimental group showed superior therapeutic effects (p<0.05) and better liver function indicators (p<0.05). Conclusion For male gout patients with reduced renal excretion, low-dose benzbromarone therapy can improve treatment efficacy while causing less impact on liver function, making it a recommended treatment option.
Key words： Low-dose febuxostat; Benzbromarone; Male gout with reduced renal excretion; Liver function
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