Clinical efficacy of negative pressure closed drainage combined with silver-containing liquid dressing in the treatment of diabetic foot
负压封闭引流联合含银液体敷料治疗糖尿病足的临床疗效研究

摘要

目的 揭示对糖尿病足患者负压封闭引流联合含银液体敷料治疗处置的临床价值。方法 2022年2月-2025年3月，将88例糖尿病足患者随机分两组，各44例，参照组常规治疗处置，研究组负压封闭引流联合含银液体敷料治疗处置，测算比照两组的治疗结果满意度测算数据值、肉芽组织覆盖率测算数据值、创面细菌清除率测算数据值、肉芽组织形态评分测算数据值，以及接受治疗前后的IL-1测算数据值、IL-6测算数据值、TNF-α测算数据值、hs-CRP测算数据值、自我管理能力评分测算数据值和生活质量评分测算数据值。结果 研究组的治疗结果满意度测算数据值高于参照组（P＜0.05）。研究组的肉芽组织覆盖率测算数据值、创面细菌清除率测算数据值，以及肉芽组织形态评分测算数据值均优于参照组（P＜0.05）。治疗前，研究组的IL-1测算数据值、IL-6测算数据值、TNF-α测算数据值、hs-CRP测算数据值、自我管理能力评分测算数据值和生活质量评分测算数据值均与参照组大致相当（P＞0.05）。治疗后，研究组的IL-1测算数据值、IL-6测算数据值、TNF-α测算数据值、hs-CRP测算数据值、自我管理能力评分测算数据值和生活质量评分测算数据值均优于参照组（P＜0.05）。结论 对糖尿病足患者负压封闭引流联合含银液体敷料治疗处置，价值充分，值得推广。

Abstract

Objective To investigate the clinical efficacy of combined negative pressure occlusive drainage and silver-containing liquid dressing therapy for diabetic foot patients.
Methods From February 2022 to March 2025,88 diabetic foot patients were randomly divided into two groups (44 each). The control group received conventional treatment, while the study group underwent combined negative pressure occlusive drainage and silver-containing liquid dressing therapy. Clinical outcomes were measured through satisfaction scores, granulation tissue coverage rate, wound bacterial clearance rate, granulation tissue morphology score, as well as IL-1, IL-6, TNF-α, hs-CRP levels, self-management ability scores, and quality of life scores before and after treatment.
Results The study group demonstrated higher satisfaction scores than the control group (P <0.05). The study group also showed superior granulation tissue coverage rate, wound bacterial clearance rate, and granulation tissue morphology score compared to the control group (P <0.05). Pre-treatment baseline values for IL-1, IL-6, TNF-α, hs-CRP, self-management ability scores, and quality of life scores in the study group were comparable to those in the control group (P> 0.05). After treatment, the study group demonstrated superior values in IL-1, IL-6, TNF-α, hs-CRP measurements, self-management ability scores, and quality of life scores compared to the control group (P <0.05).
Conclusion   The combined therapy of negative pressure occlusive drainage and silver-containing liquid dressing for diabetic foot patients demonstrates significant efficacy and is clinically recommended for widespread adoption.