Analysis of related factors of recurrence in patients with hyperthyroidism after drug withdrawal in the early stage of pregnancy and its impact on pregnancy outcomes
甲亢患者妊娠早期停药后复发的相关因素及对妊娠结局的影响分析

摘要

目的 探究甲亢患者妊娠早期停药后复发的相关因素及对妊娠结局的影响。方法 选取本院甲亢妊娠早期停药患者94例，时间2024年6月—2025年6月，根据患者复发情况，分为复发组（36例）和未复发组（58例），对患者复发的相关因素及对妊娠结局的影响进行回顾性分析。结果 年龄、甲亢病程、甲状腺功能指标、甲状腺自身抗体、家族史等因素，均会对甲亢患者妊娠早期停药后复发造成影响，同时复发组不良妊娠结局发生率高于未复发组，差异有统计学意义（P＜0.05）。结论 针对甲亢患者妊娠早期停药后复发问题，需基于高危因素，制定个体化干预策略，以控制复发问题，改善妊娠结局。

Abstract

Objective To explore the related factors of recurrence in patients with hyperthyroidism after drug withdrawal in the early stage of pregnancy and its impact on pregnancy outcomes.
Methods A total of 94 patients with hyperthyroidism who discontinued medication in the early stage of pregnancy in our hospital were selected from June 2024 to June 2025. According to the recurrence situation of the patients, they were divided into the recurrence group (36 cases) and the non-recurrence group (58 cases). A retrospective analysis was conducted on the related factors of recurrence and their impact on pregnancy outcomes.
Results Factors such as age, duration of hyperthyroidism, thyroid function indicators, thyroid autoantibodies, and family history all have an impact on the recurrence of hyperthyroidism patients after drug withdrawal in the early stage of pregnancy. Meanwhile, the incidence of adverse pregnancy outcomes in the recurrence group was higher than that in the non-recurrence group, and the difference was statistically significant (P < 0.05).
Conclusion   For the recurrence problem of hyperthyroidism patients after drug withdrawal in the early stage of pregnancy, individualized intervention strategies should be formulated based on high-risk factors to control the recurrence problem and improve pregnancy outcomes.