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Open Access Article

International Journal of Clinical Research. 2026; 10: (1) ; 20-25 ; DOI: 10.12208/j.ijcr.20260006.

Research progress in the treatment of variceal rupture and bleeding with vasoactive drugs
食管胃底曲张静脉破裂出血血管活性药物治疗研究进展

作者: 苏雪1, 郑盛2 *, 黄远飞1, 魏艳芳1, 李正登1

1 大理大学临床医学院 云南大理

2 大理大学第二附属医院 云南昆明

*通讯作者: 郑盛,单位: 大理大学第二附属医院 云南昆明;

发布时间: 2026-01-28 总浏览量: 53

摘要

食管胃底静脉曲张破裂出血(EGVB)是肝硬化门静脉高压症的严重并发症,死亡率高。血管活性药物能够快速降低门静脉压力,是EGVB急性期止血和预防早期再出血的一线治疗手段。本文系统综述了血管加压素类(垂体后叶素、特利加压素)、生长抑素类(奥曲肽、生长抑素)药物、新型靶向药物(如OCE-205)和肾上腺类药物β受体阻滞剂在EGVB单药治疗中的临床证据、作用机制、疗效与安全性。

关键词: 食管胃底静脉曲张破裂出血;门静脉高压;血管活性药物;特利加压素;奥曲肽

Abstract

Esophagogastric Variceal Bleeding (EGVB) is a severe complication of cirrhotic portal hypertension with a high mortality rate. Vasoactive drugs can rapidly reduce portal pressure, and serve as the first-line treatment modality for hemostasis in the acute phase of EGVB and prevention of early rebleeding. This article systematically reviews the clinical evidence, mechanisms of action, efficacy and safety of vasopressin agents (vasopressin, terlipressin), somatostatin agents (octreotide, somatostatin), novel targeted drugs (e.g., OCE-205), and adrenal β-adrenergic receptor blockers in monotherapy for EGVB.

Key words: Esophagogastric Variceal Bleeding; Portal hypertension; Vasoactive drugs; Terlipressin; Octreotide

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引用本文

苏雪, 郑盛, 黄远飞, 魏艳芳, 李正登, 食管胃底曲张静脉破裂出血血管活性药物治疗研究进展[J]. 国际临床研究杂志, 2026; 10: (1) : 20-25.