The clinical value of detecting tumor necrosis factor-a, interleukin-6, and interleukin-17A in ovarian malignant tumors
肿瘤坏死因子-a、白细胞介素-6、白细胞介素-17A的检测在卵巢恶性肿瘤中的临床价值

摘要

目的 探讨肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-17A（IL-17A）用作临床诊断卵巢恶性肿瘤疾病的价值。方法 以邳州市人民医院2023年1月-2024年12月妇科接诊卵巢恶性肿瘤疾病患者90例作为观察组研究对象，选择同期该院90例体检健康女性作为对照组研究对象。检验TNF-α、IL-6及IL-17A，对比两组研究对象检查结果。结果 观察组三项指标均高于对照组（p＜0.05）。观察组卵巢恶性肿瘤疾病患者中，随着疾病分期增长，三项指标呈现增高趋势，其中以IV期患者三项指标最高（p＜0.05）。结论 通过检测TNF-α、IL-6、IL-17A指标可作为临床诊断卵巢恶性肿瘤疾病的依据，同时通过数值范围辅助判断疾病分期，值得借鉴。

Abstract

Objective To explore the value of tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), and interleukin-17A (IL-17A) in the clinical diagnosis of ovarian malignant tumor diseases.
Methods A total of 90 patients with ovarian malignant tumors who were treated in the gynecology department of Pizhou People's Hospital from January 2023 to December 2024 were selected as the research subjects of the observation group, and 90 healthy women who underwent physical examinations in the same hospital during the same period were selected as the research subjects of the control group. TNF-α, IL-6 and IL-17A were examined, and the examination results of the two groups of research subjects were compared.
Results The three indicators of the observation group were all higher than those of the control group (p < 0.05). Among the patients with ovarian malignant tumors in the observation group, with the increase of disease stage, the three indicators showed an increasing trend, among which the three indicators of patients in stage IV were the highest (p < 0.05).
Conclusion   The detection of TNF-α, IL-6 and IL-17A indicators can serve as a basis for the clinical diagnosis of ovarian malignant tumor diseases. Meanwhile, the numerical range can assist in determining the disease stage, which is worth learning from.