Clinical efficacy and safety of Traditional Chinese Medicine ultrasound-guided drug delivery device in treating children with tic disorders comorbid with attention deficit hyperactivity disorder
中医超声导药仪治疗儿童抽动障碍共患注意缺陷多动障碍的临床有效性和安全性

摘要

目的 深入细致的分析探讨中医超声导药仪治疗儿童抽动障碍（TD）共患注意缺陷多动障碍（ADHD）的临床有效性和安全性，期待能为临床研究提供理论与实践的双重参照。方法 研究期限设立为2023年9月至2024年9月，分析样本抽取自本时段院内收治的TD共患ADHD患儿中（均符合DSM-5诊断标准），归纳人数70例（均接受中医超声导药仪治疗）。导入药品依据平肝熄风、宁心安神的原则进行组方，通过透皮给药的方式作用于百会、四神聪、风池、太冲、内关等穴位。干预时长，每周3次，4周为1疗程，持续干预8周。而后对相关数据展开收集整理，以YGTSS评分、SNAP-IV评分、总有效率、不良反应为观察指标，评价中医超声导药仪的实际应用效果。结果 统计学分析后发现，患儿总体有效率达87.14％，显优治疗前（P＜0.05）。结论 中医导药仪的应用实施，一方面能切实改善TD共患ADHD患儿抽动症状和注意力不集中、多动冲动行为，且不良反应较少，是一项无创的治疗方法，更适合儿童临床应用，望采纳。

Abstract

Objective This study aims to conduct an in-depth analysis of the clinical efficacy and safety of Traditional Chinese Medicine (TCM) ultrasonic-guided drug delivery device in treating childhood tic disorder (TD) co-occurring with attention deficit hyperactivity disorder (ADHD), providing theoretical and practical references for clinical research.
Methods The study period was set from September 2023 to September 2024. The sample was drawn from hospitalized children with TD co-occurring with ADHD (all meeting DSM-5 diagnostic criteria), totaling 70 cases (all receiving TCM ultrasonic-guided drug delivery device treatment). The herbal formula was formulated based on the principles of "harmonizing liver and calming wind" and "calming the mind and soothing the spirit," administered through transdermal drug delivery to acupoints including Baihui, Sishencong, Fengchi, Taichong, and Neiguan. Intervention duration: 3 sessions per week, with 4 weeks per course, totaling 8 weeks. Data collection and analysis were performed using YGTSS scores, SNAP-IV scores, total effective rate, and adverse reactions as evaluation indicators.
Results Statistical analysis revealed an overall effective rate of 87.14% in children, showing significant improvement compared to pre-treatment levels (P<0.05).
Conclusion   The application of TCM drug delivery devices can effectively alleviate tic symptoms, attention deficits, and hyperactive impulsive behaviors in children with TD co-occurring with ADHD. With fewer adverse reactions, this non-invasive treatment method is particularly suitable for pediatric clinical use. The findings are recommended for clinical adoption.