Nursing observation and intervention measures for filter coagulation in severe blood purification under different anticoagulation regimens
不同抗凝方案下重症血液净化滤器凝血的护理观察与干预措施

摘要

目的 观察普通肝素、低分子肝素、枸橼酸钠三种抗凝方案对重症血液净化滤器凝血的影响及护理干预效果。方法 选取2024年1月—2025年6月176例重症血液净化患者，分A（普通肝素，58例）、B（低分子肝素，58例）、C（枸橼酸钠，60例）组，均实施针对性护理，比较滤器凝血等指标。结果 C组滤器凝血发生率（6.67%）低于A（31.03%）、B组（17.24%），滤器使用寿命（45.89±6.02h）长于A、B组，出血发生率（3.33%）低于A、B组（P<0.05）。结论 枸橼酸钠抗凝联合护理干预可降低滤器凝血及出血风险，延长滤器寿命。

Abstract

Objective To observe the effects of three anticoagulation regimens, namely unfractionated heparin, low - molecular - weight heparin, and sodium citrate, on filter coagulation in severe blood purification and the effects of nursing interventions.
Methods A total of 176 patients undergoing severe blood purification from January 2024 to June 2025 were selected and divided into Group A (unfractionated heparin, 58 cases), Group B (low - molecular - weight heparin, 58 cases), and Group C (sodium citrate, 60 cases). Targeted nursing was implemented for all groups, and indicators such as filter coagulation were compared.
Results The incidence of filter coagulation in Group C (6.67%) was lower than that in Group A (31.03%) and Group B (17.24%). The service life of the filter in Group C (45.89 ± 6.02 h) was longer than that in Group A and Group B, and the incidence of bleeding in Group C (3.33%) was lower than that in Group A and Group B (P < 0.05).
Conclusion   Anticoagulation with sodium citrate combined with nursing intervention can reduce the risks of filter coagulation and bleeding, and prolong the service life of the filter.