摘要
目的 探讨PTCD治疗对恶性梗阻性黄疸(MOJ)患者的影响。方法 选取南京医科大学附属淮安第一医院介入科于2022年3月-2025年3月收治的MOJ患者100例,根据随机数字表法将其分为观察组(n=50,实施鼻肠营养管置入辅助PTCD治疗)和对照组(n=50,实施PTCD治疗),对比两组肝功能指标、营养指标及并发症。结果 观察组肝功能指标水平均低于对照组;观察组ALB、PA水平均高于对照组;观察组并发症总发生率低于对照组(P<0.05)。结论 鼻肠营养管置入辅助PTCD治疗可促进MOJ患者肝功能恢复,改善其营养状态,并降低并发症发生率。
关键词: 恶性梗阻性黄疸;肠内营养;鼻肠营养管;经皮肝穿刺胆道引流术;营养指标;肝功能
Abstract
Objective To investigate the effect of PTCD treatment on patients with malignant obstruct jaundice (MOJ). Methods A total of 100 patients with MOJ treated in the Department of Interventional Radiology of the First Affiliated of Nanjing Medical University from March 2022 to March 2025 were selected. According to the randomized numerical table method, they were divided into the observation (n=50, nasojejunal enteral nutrition tube placement was performed to assist PTCD treatment) and the control group (n=50, PTCD treatment performed). The levels of liver function indexes, nutritional indexes and complications in the two groups were compared. Results The levels of liver function indexes in the observation group were all than those in the control group; the levels of ALB and PA in the observation group were higher than those in the control group; the total incidence rate of complications in the observation was lower than that in the control group (P < 0.05). Conclusion Nasojejunal enteral nutrition tube placement to assist PTCD treatment promote the recovery of liver function in patients with MOJ, improve their nutritional status, and reduce the incidence of complications.
Key words: Malignant obstructive jaundice; Enteral nutrition; Nasojejunal feeding tube; Percutaneous transhepaticolangial drainage; Nutritional index; Hepatic function
参考文献 References
[1] 姚继瑶,宫瑜,王晶,等. 恶性梗阻性黄疸PTCD术后胆道感染与外周血sCD14-ST、PCT、TLR4 和TLR2表达的关联[J]. 中华医院感染学杂志,2025,35(5):672-676.
[2] 钟海,陈剑挺,胡小龙,等. 新型胆道引流管固定装置在经皮肝穿刺胆道引流术后患者中的应用效果[J]. 广西医学, 2023,45(18):2280-2282,2290.
[3] 郑玉梅,蔡珍玉,傅高航. 超声引导下经皮肝穿刺胆道置管引流术治疗恶性梗阻性黄疸的临床效果观察[J]. 浙江医学,2024,46(15):1643-1645.
[4] 张华安,周晓芳,蒋易君,等. NRS-2002联合炎症反应标志物预测恶性梗阻性黄疸患者预后的Nomogram模型构建[J]. 山东医药,2021,61(16):35-40.
[5] 韦红艳. 危重患者肠内营养中超声辅助床旁鼻空肠管置入术的作用[J]. 吉林医学,2024,45(11):2868-2871.
[6] 刘静雯,倪春湘,吴承骏,等. 全程营养监测联合鼻饲肠内营养在食管癌放射治疗中的应用[J]. 肠外与肠内营养, 2023, 30(2):80-84.
[7] 贾亚亚,孟庆乾,于慧艳,等. 鼻肠管联合鼻胃管营养对危重症患者胆系相关指标的影响分析[J]. 中国中西医结合急救杂志,2025,32(1):48-54.
[8] 程艳莉,王苗苗,钟慧娟,等. 经鼻胃管肠内喂养对食管癌患者放化疗期间营养状况及身体状态的影响[J]. 肿瘤代谢与营养电子杂志,2024,11(4):553-558.
[9] 杨丽晖,徐凤娟,靳晓倩,等. SAP患者鼻胃管肠内营养时机选择及肠源性感染指标表达水平的变化分析[J]. 中国中西医结合急救杂志,2023,30(2):199-203.
[10] 席江伟,王艳,张文双,等. 营养支持联合胆汁回输对行经皮肝穿刺胆道引流术晚期恶性梗阻性黄疸患者预后及生活质量的影响[J]. 河北北方学院学报(自然科学版), 2025, 41(10):38-42.