Sequential therapy of “Lung-Clearing and Phlegm-Resolving Acupoint Embedding” for treating phlegm-heat congestive lung syndrome in ACOS: clinical efficacy and airway remodeling mechanism
“清肺化痰+穴位埋线”序贯疗法治疗ACOS痰热郁肺证的临床疗效及气道重塑机制

摘要

目的 探讨“清肺化痰+穴位埋线”序贯疗法治疗ACOS痰热郁肺证的临床疗效及气道重塑机制。方法 本研究纳入2024年1月-2025年1月期间ACOS痰热郁肺证患者67例为研究对象，采用随机数字表法将受试者均分为两组。常规组实施清肺化痰治疗，研究组实施“清肺化痰+穴位埋线”序贯疗法治疗，比较两组临床疗效、治疗周期、住院天数、肺功能指标及炎症因子水平变化、生活质量。结果 研究组在总体治疗效果上明显优于常规组（P<0.05）。从治疗时长来看，研究组患者的治疗周期和住院时间均较常规组显著缩短（P<0.05）。通过肺功能检查发现，研究组在FEV1、FVC等关键指标的提升幅度显著超过常规组（P<0.05）。炎症指标检测结果显示，研究组血清IL-6、TNF-α等炎性因子水平下降幅度大于常规组（P<0.05）。研究组生活质量数值比常规组高（P<0.05）。结论 “清肺化痰+穴位埋线”序贯疗法可显著提升ACOS痰热郁肺证患者的临床疗效，缩短治疗周期与住院时间，改善肺功能、抑制炎症反应以调控气道重塑，同时提高生活质量，具有较高的临床应用价值。

Abstract

Objective To investigate the clinical efficacy and airway remodeling mechanism of the sequential therapy of 'clearing the lungs and resolving phlegm combined with acupoint embedding' in the treatment of ACOS with phlegm-heat congested lung syndrome.
Methods This study enrolled 67 patients with ACOS and phlegm-heat congested lung syndrome from January 2024 to January 2025. The participants were randomly divided into two groups using a random number table. The conventional group received standard therapy for clearing the lungs and resolving phlegm, while the study group received the sequential therapy of 'clearing the lungs and resolving phlegm combined with acupoint embedding.' Clinical efficacy, treatment duration, length of hospital stay, changes in pulmonary function indicators and inflammatory factor levels, and quality of life were compared between the two groups.
Results The overall treatment effectiveness in the study group was significantly better than that in the conventional group (P<0.05). In terms of treatment duration, the study group had significantly shorter treatment courses and hospital stays compared to the conventional group (P<0.05). Pulmonary function tests showed that the improvement in key indicators such as FEV1 and FVC was significantly greater in the study group than in the conventional group (P<0.05). Inflammatory marker measurements indicated that the reduction in serum levels of inflammatory factors such as IL-6 and TNF-α was larger in the study group than in the conventional group (P<0.05). The study group also had higher quality of life scores than the conventional group (P<0.05).
Conclusion   The sequential therapy of 'clearing the lungs and resolving phlegm combined with acupoint embedding' can significantly improve the clinical efficacy in patients with ACOS and phlegm-heat congested lung syndrome, shorten treatment duration and hospital stays, enhance lung function, suppress inflammatory responses to regulate airway remodeling, and improve quality of life, demonstrating high clinical application value.