Based on the theory of chronology, this paper explores the therapeutic effect of acupuncture at the hour of Si and Wu in the treatment of insomnia caused by deficiency of both heart and spleen and its influence on serum 5-HT and GABA
基于时间医学理论探讨巳午时针刺治疗心脾两虚型失眠的疗效及对血清5-HT、GABA影响

摘要

目的 观察对心脾两虚型失眠患者开展基于时间医学理论探讨的巳午时针刺治疗效果及对患者血清5-羟色胺(5-HT)、γ-氨基丁酸(GABA)影响。方法 在本院2024年3月至2025年4月心脾两虚型失眠患者中选择60例，按照随机顺序的方式来将患者分成数量相同的两个组别，一组为巳午时针刺组，另一组为非巳午时针刺组，每组各30例。对患者睡眠质量、血清5-HT、GABA水平变化进行观察。结果 试验组治疗后睡眠质量高于对照组，P<0.05。试验组治疗后血清5-HT、GABA水平均明显高于对照组，P<0.05。结论 基于时间医学理论探讨的巳午时针刺治疗可有效提升心脾两虚型失眠患者的睡眠质量，上调血清5-HT、GABA水平，为心脾两虚型失眠的临床治疗提供新思路。

Abstract

Objective To observe the therapeutic effect of acupuncture at the hour of Si and Wu based on the theory of time medicine on patients with insomnia caused by deficiency of both heart and spleen, and its influence on serum 5-hydroxytryptamine (5-HT) and gamma-aminobutyric acid (GABA) in patients.
Methods Sixty patients with insomnia due to deficiency of both heart and spleen in our hospital from March 2024 to April 2025 were selected and randomly divided into two groups of the same number. One group was the acupuncture group at the hour of Si and wu, and the other group was the non-Si and Wu acupuncture group, with 30 cases in each group. The changes in sleep quality, serum 5-HT and GABA levels of the patients were observed.
Results The sleep quality of the experimental group after treatment was higher than that of the control group, P<0.05. After treatment, the levels of serum 5-HT and GABA in the experimental group were significantly higher than those in the control group, P<0.05.
Conclusion   Acupuncture treatment at the hour of Si and Wu based on the theory of chronology can effectively improve the sleep quality of patients with insomnia caused by deficiency of both heart and spleen, and upregulate the levels of serum 5-HT and GABA, providing a new idea for the clinical treatment of insomnia caused by deficiency of both heart and spleen.