摘要
目的 将重复经颅磁刺激(rTMS)用于孤独症谱系障碍(ASD)患儿中,对其应用效果进行探究。方法 选取2024年3月-2025年5月本院收治的70例ASD患儿,随机分组,对照组35例行常规康复治疗,观察组35例在此基础上予以rTMS治疗,对两组干预结果进行比较。结果 治疗前,两组感觉、躯体运动、交往各项ABC评分比较,不具显著差异(P>0.05),治疗后,观察组各项ABC评分更低(P<0.05);治疗前,两组CARS、ATEC评分比较,不具显著差异(P>0.05),治疗后,观察组各评分更低(P<0.05);观察组患儿治疗完成<10次、10~19次、20次比例分别为14.29%、34.29%、94.29%,与对照组比较有显著差异(P<0.05)。结论 对ASD患儿来说,应用rTMS治疗可较好改善患儿孤独行为及孤独症状,更好改善其病情,并提高患儿治疗完成度,具有较高应用价值。
关键词: 孤独症谱系障碍;重复经颅磁刺激;康复治疗
Abstract
Objective To explore the application effect of repetitive transcranial magnetic stimulation (rTMS) in children with autism spectrum disorder (ASD). Methods A total of 70 children with ASD admitted to our hospital from March 2022 to May 2025 were selected and randomly grouped. 35 cases in the control group received conventional rehabilitation treatment, while 35 cases in the observation group were treated with rTMS on this basis. The intervention results of the two groups were compared. Results Before treatment, there was no significant difference in the ABC scores of sensation, somatomotor, and interaction between the two groups (P>0.05). After treatment, the ABC scores of each item in the observation group were lower (P<0.05). Before treatment, there was no significant difference in the CARS and ATEC scores between the two groups (P>0.05). After treatment, the scores of each group in the observation group were lower (P<0.05). The proportions of children in the observation group who completed treatment < 10 times, 10-19 times, and 20 times were 14.29%, 34.29%, and 94.29% respectively, which were significantly different from those in the control group (P<0.05). Conclusion For children with ASD, the application of rTMS treatment can better improve their lonely behaviors and symptoms, better improve their condition, and increase the completion rate of treatment for children, which has high application value.
Key words: Autism spectrum disorder; Repetitive transcranial magnetic stimulation; Rehabilitation therapy
参考文献 References
[1] 詹英杰,文宇,黄伟庆,等.重复经颅磁刺激对孤独症谱系障碍儿童心理行为及情绪的影响[J].当代医学, 2024, 30(16): 18-21.
[2] 张莹,王磊,段园菊. 团体认知行为干预联合重复经颅磁刺激对小儿孤独症谱系障碍睡眠质量及行为状态的影响[J]. 国际精神病学杂志,2024,51(2):433-437.
[3] 朱利强. 经颅重复高频磁刺激左侧Broca区与左侧背外侧前额叶区治疗小儿孤独症谱系障碍的临床效果[J]. 临床医学研究与实践,2021,6(24):94-96.
[4] 努尔帕夏·阿布拉,买西热木·司马义. 高频重复经颅磁刺激联合感觉统合训练干预对孤独症谱系障碍患儿自闭程度、行为及睡眠质量的影响[J]. 反射疗法与康复医学,2025,6(4):94-97.
[5] 李琳. 经颅重复高频磁刺激联合康复训练治疗小儿孤独症谱系障碍效果及安全性分析[J]. 反射疗法与康复医学,2020,29(1):8-9,12.
[6] 刘超宇,胡继红,何金华,等. rTMS联合综合康复干预对孤独症谱系障碍患儿临床症状及语言功能康复的影响[J]. 中国听力语言康复科学杂志,2024,22(2):221-224.
[7] 冯君,李梅,陈丽琴,等. 重复经颅磁刺激联合音乐疗法对孤独症谱系障碍儿童的治疗作用研究[J]. 现代医学与健康研究(电子版),2024,8(15):4-8.
[8] 李梅,冯君,吴霞,等. 重复经颅磁刺激联合音乐疗法对孤独症谱系障碍儿童的治疗作用研究[J]. 大医生,2022, 7(8): 141-144.
[9] 黄肖霞,温慧玲,凡伟,等. 重复经颅磁刺激治疗孤独症谱系障碍患儿行为问题的临床效果对照研究[J]. 中国妇幼保健,2024,39(9):1608-1611.
[10] 魏伦伦. 重复经颅磁刺激对儿童孤独症谱系障碍的效果及对其心理情绪的影响[J]. 心理月刊,2021,13(3):40-41,43.
[11] 张烨. 经颅重复高频磁刺激联合分阶综合社交技能训练在孤独症谱系障碍患儿中的应用效果[J]. 妇儿健康导刊,2025,4(5):61-64,82.
[12] 万凯,尚清,吕楠. Broca区高频重复经颅磁刺激、可视音乐、镜像视觉反馈疗法三联治疗学龄期孤独症患儿的效果[J]. 中国民康医学,2022,34(7):93-95,99.
[13] 林盛武. 高频重复经颅磁刺激配合左旋肉碱治疗儿童孤独症谱系障碍的效果及对脑电生理指标的作用[J]. 医学理论与实践,2022,35(23):4055-4057.