Observation of the therapeutic effect of early application of budesonide nebulization and ambroxol in the treatment of pulmonary contusion
肺挫伤治疗早期应用布地奈德雾化和使用氨溴索的疗效观察

摘要

目的 探讨布地奈德雾化联合氨溴索在肺挫伤患者早期治疗中的临床疗效与可行性。方法 选取2023年7月至2024年12月期间我院收治的90例明确诊断为肺挫伤的患者，按入院顺序随机分为观察组与对照组，各45例。对照组给予常规抗感染、止血、氧疗等基础治疗，观察组在此基础上应用布地奈德雾化吸入联合静脉使用氨溴索针（30mg，2次/天）或口服氨溴索片（60mg，3次/天）。比较两组患者治疗后第7天的咳嗽缓解时间、呼吸困难评分变化、肺部啰音消失率、胸部CT改善情况及住院天数。结果 观察组咳嗽缓解时间明显短于对照组（P<0.05），第7天呼吸困难评分改善更明显（P<0.05），肺部啰音消失率及胸部CT改善率高于对照组（P<0.05），住院天数平均缩短2.3天，差异具有统计学意义。结论 布地奈德雾化吸入联合使用溴索可显著改善肺挫伤患者早期呼吸道症状、促进肺部恢复，缩短住院时间，适合在医院推广使用。

Abstract

Objective To explore the clinical efficacy and feasibility of budesonide nebulization combined with ambroxol in the early treatment of patients with pulmonary contusion.
Methods Ninety patients diagnosed with pulmonary contusion admitted to our hospital from July 2023 to December 2024 were randomly divided into an observation group and a control group, with 45 cases in each group, according to the admission order. The control group received routine basic treatments such as anti infection, hemostasis, and oxygen therapy, while the observation group received a combination of intravenous ambroxol injections (30mg, twice a day) or oral ambroxol tablets (60mg, three times a day) on this basis. Compare the cough relief time, changes in dyspnea score, disappearance rate of lung rales, improvement of chest CT, and length of hospital stay between two groups of patients on the 7th day after treatment.
Results The cough relief time in the observation group was significantly shorter than that in the control group (P<0.05), and the improvement in dyspnea score on the 7th day was more significant (P<0.05). The disappearance rate of lung rales and the improvement rate of chest CT were higher than those in the control group (P<0.05). The average length of hospital stay was shortened by 2.3 days, and the difference was statistically significant.
Conclusion   The combination of budesonide nebulization and intravenous application of ambroxol can significantly improve early respiratory symptoms, promote lung recovery, shorten hospitalization time in patients with pulmonary contusion, and is suitable for promotion and use in hospitals.