Observation of the clinical efficacy of Zhixue Zhentong Capsules combined with conventional Western medicine in the treatment of osteoarthritis
止血镇痛胶囊联合常规西药治疗骨性关节炎的临床疗效观察

摘要

目的 本研究旨在探讨止血镇痛胶囊联合常规西药对骨性关节炎疗效。方法 共入组70例患者，随机分为每组35例的两组患者。观察组行常规西药联合止血镇痛胶囊治疗，对照组行常规西药给药。以临床疗效、生活质量分数、视觉模拟量表评分（VAS）、日本骨科协会评估治疗分数（JOA）、肿瘤坏死因子-α、白介素-6等角度评估，比较临床效果。结果 研究数据显示，两组患者在人口学特征上无差异（P＞0.05）。观察组患者的临床疗效、生活质量分数、VAS、JOA、肿瘤坏死因子-α、白介素-6、肿胀等指标较对照组更佳（97.14% vs.85.71%；78.73±5.23 vs.61.23±4.52，79.63±4.75 vs.62.46±4.57，81.36±4.37 vs.70.26±5.83，78.30±6.53 vs.62.26±4.46；1.24±1.24 vs.2.33±2.32，88.52±2.52 vs.84.46±5.42；63.35±8.14 vs.69.22±8.42，56.28±6.43 vs.61.36±6.36，1.32±0.42 vs.1.86±0.38；P＜0.05）；研究期间，观察组骨性关节炎患者出现恶心、头晕等不良反应的发生率显著低于对照组（P＜0.05）。研究结果表明，止血镇痛胶囊在骨性关节炎的治疗中有良好效果，不良反应较少，可应用于临床。

Abstract

Objective This study aims to explore the therapeutic effect of Zhixue Zhentong Capsules combined with conventional Western medicine on osteoarthritis.
Methods A total of 70 patients were enrolled and randomly divided into two groups of 35 patients each. The experimental group received conventional Western medicine combined with Zhixue Zhentong Capsules treatment, while the control group received conventional Western medicine administration. Evaluate the clinical efficacy, quality of life score, visual analog scale (VAS) score, Japanese Orthopaedic Association Evaluation of Treatment Score (JOA), tumor necrosis factor alpha, interleukin-6, and other aspects to compare the clinical outcomes. The research data showed that there was no significant difference in demographic characteristics between the two groups of patients (P>0.05). Observe the clinical efficacy and quality of life scores of patients in the observation group VAS JOA Tumor necrosis factor alpha, interleukin-6, swelling and other indicators were better in the control group than in the control group (97.14% vs. 85.71%; 78.73 ± 5.23 vs. 61.23 ± 4.52, 79.63 ± 4.75 vs. 62.46 ± 4.57, 81.36 ± 4.37 vs. 70.26 ± 5.83, 78.30 ± 6.53 vs. 62.26 ± 4.46); 1.24±1.24 vs.2.33±2.32，88.52±2.52 vs.84.46±5.42; 63.35±8.14 vs.69.22±8.42，56.28±6.43 vs.61.36±6.36, 1.32±0.42 vs.1.86±0.38; P＜0.05); During the study, the incidence of adverse reactions such as nausea and dizziness in patients with osteoarthritis in the observation group was significantly lower than that in the control group (P<0.05). The research results indicate that Zhixue Zhentong Capsules have good efficacy in the treatment of osteoarthritis, with fewer adverse reactions, and can be applied in clinical practice.