Clinical effect of new activated substance combined with safflower oral liquid in the treatment of refractory heart failure
新活素联合西红花口服液治疗难治性心力衰竭临床效果研究

摘要

目的 探究新活素联合西红花口服液治疗2024年1月-2024年12月本院收治的50例难治性心力衰竭患者，随机分为对照组和观察组，每组25例。对照组采用常规抗心力衰竭治疗，观察组在常规治疗基础上联合使用新活素与西红花口服液。比较两组患者治疗前后的心功能指标（左心室射血分数、左心室舒张末期内径）、6分钟步行距离、BNP水平及临床疗效。结果 治疗后，观察组左心室射血分数提升至（48.2±5.1）%，显著高于对照组的（42.3±4.8）%；左心室舒张末期内径缩小至（55.6±4.3）mm，小于对照组的（59.8±4.7）mm；6分钟步行距离大于对照组；BNP水平降至（1256.3±215.4）pg/mL，低于对照组的（1789.5±246.7）pg/mL，差异均有统计学意义（P<0.05）。观察组总有效率达88.0%（22/25），高于对照组的68.0%（17/25）（P<0.05）。结论 新活素联合西红花口服液治疗难治性心力衰竭，可有效改善患者心功能，提高运动耐力，降低神经内分泌因子水平，临床效果显著，值得推广。

Abstract

Objective To investigate the efficacy of Xin Huo Su combined with Red Flower Oral Liquid in treating 50 patients with refractory heart failure admitted to our hospital from January 2024 to December 2024. The patients were randomly divided into a control group and an observation group, each consisting of 25 patients. The control group received conventional anti-heart failure treatment, while the observation group received Xin Huo Su and Red Flower Oral Liquid in addition to conventional treatment. The study compared the heart function indicators (left ventricular ejection fraction, left ventricular end-diastolic diameter), 6-minute walk distance, BNP levels, and clinical outcomes before and after treatment.
Results After treatment, the left ventricular ejection fraction of the observation group increased to (48.2±5.1)% compared to the control group's (42.3±4.8)%; the left ventricular end-diastolic diameter decreased to (55.6±4.3)mm compared to the control group's (59.8±4.7)mm; the 6-minute walk distance was greater than that of the control group; BNP levels decreased to (1256.3±215.4)pg/mL compared to the control group's (1789.5±246.7)pg/mL, with all differences being statistically significant (P<0.05). The overall effective rate of the observation group reached 88.0% (22/25), significantly higher than the control group's 68.0% (17/25) (P<0.05).
Conclusion   Xin Huo Su combined with Red Flower Oral Liquid is effective in treating refractory heart failure, improving heart function, enhancing exercise endurance, and reducing neuroendocrine factor levels, with significant clinical outcomes, making it worthy of promotion.