Expression characteristics and correlation analysis of glycosylated hemoglobin and hemoglobin in patients with type 2 diabetes mellitus at high altitude
高海拔地区2型糖尿病患者糖化血红蛋白、血红蛋白表达特征及相关性分析

摘要

目的 探讨高海拔地区2型糖尿病患者（T2DM）的糖化血红蛋白（HbAlc）、血红蛋白（Hb）表达特征及其相关性。方法 选取高海拔地区青海省海南州（海拔3000m）人民医院内分泌科T2DM患者119例和西宁市（海拔2200m）第三人民医院内分泌科116例及低海拔地区上海市（海拔2.19m）复旦大学附属医院糖尿病研究所200例作为糖尿病组与同期健康体检非糖尿病患者15例作为对照组。结果 糖尿病组患者血清Hb、HbAlc等五项指标均高于正常组，白蛋白、中性粒细胞、淋巴细胞均低于正常组（P<0.05）。结论 高海拔地区T2DM表现出HbAlc、Hb的高表达特征，且两者之间有紧密正向关联性，表明Hb可能会对高海拔地区T2DM患者HbAlc带来一定程度的影响，可以联合多项指标来综合判断。

Abstract

Objective To explore the expression characteristics and correlation of glycosylated hemoglobin (HbAlc) and hemoglobin (Hb) in patients with type 2 diabetes mellitus (T2DM) at high altitude.
Methods 119 patients with T2DM from the Department of Endocrinology, People's Hospital of Hainan Prefecture, Qinghai Province (at an altitude of 3000m), 116 patients from the Department of Endocrinology, Third People's Hospital of Xining City (at an altitude of 2200m) and 200 patients from the Institute of Diabetes in the Affiliated Hospital of Fudan University in Shanghai (at an altitude of 2.19m) were selected as diabetes group and 15 non-diabetic patients as control group.
Results T2DM at high altitude shows the high.
Conclusion   The serum Hb, HbAlc and other five indexes in the diabetic group were higher than those in the normal group, while albumin, neutrophils and lymphocytes were lower than those in the normal group (P<0.05). expression characteristics of HbAlc and Hb, and there is a close positive correlation between them, which indicates that Hb may have some influence on HbAlc of T2DM patients at high altitude, which can be comprehensively judged by combining multiple indexes.