Analysis of the efficacy of tenecteplase and alteplase in thrombolytic treatment of acute cerebral infarction
替奈普酶与阿替普酶溶栓治疗急性脑梗死的疗效分析

摘要

目的 分析阿替普酶（rt-PA）溶栓、替奈普酶（TNK））溶栓治疗急性脑梗死（ACI）的效用。方法 2024年2月~2025年2月，取我院ACI 112例患者，纳入标准：ACI确诊患者；起病时间应少于4.5h；NIHSS<20分。排除标准：存在脑出血体征；心血管严重病症；凝血功能障碍；近期实施外科手术治疗。均等随机分组，各组均56例，对照组+ rt-PA溶栓，观察组+ TNK溶栓，分析组间疗效。结果 治疗后，组间生化指标、NIHSS（美国国立卫生研究院脑卒中量表）评分、MBI（Barthel 指数分级法）评分（P>0.05）；观察组疗效、不良反应均较对照组更优（P<0.05）。结论 ACI患者行TNK、rt-PA 溶栓均利于神经、凝血功能改善，日常活动能力提高，对比rt-PA 溶栓，TNK溶栓价值更为有效、安全、方便。

Abstract

Objective To analyze the efficacy of thrombolysis with alteplase (rt-PA) and Teneplase (TNK) in the treatment of acute cerebral infarction (ACI).
Methods From February, 2024 to February, 2025, 112 patients with ACI in our hospital were selected, and the inclusion criteria were: confirmed patients with ACI; The onset time should be less than 4.5h; NIHSS<20 points. Exclusion criteria: there are signs of cerebral hemorrhage; Serious cardiovascular diseases; Coagulation dysfunction; Surgical treatment was performed recently. Randomly and equally, 56 cases in each group, the control group+RT-PA thrombolysis, the observation group+TNK thrombolysis, and the curative effect between groups was analyzed.
Results After treatment, biochemical indexes, NIHSS (National Institutes of Health Stroke Scale) score and MBI(Barthel Index Classification) score between groups (P＞0.05); The curative effect and adverse reactions of the observation group were better than those of the control group (P＜0.05).
Conclusion   Thrombolysis with TNK and rt-PA in ACI patients is beneficial to the improvement of nerve and coagulation function and the ability of daily activities. Compared with rt-PA thrombolysis, TNK is more effective, safe and convenient.