Determination and correlation analysis of serum glycosylated protein and glycosylated hemoglobin in patients with type 2 diabetes at high altitude
高海拔地区2型糖尿病患者血清糖化蛋白、糖化血红蛋白的测定及相关性分析

摘要

目的 探讨在高海拔地区2型糖尿病（T2DM）患者血清糖化蛋白（GSP）、糖化血红蛋白（HbA1c）的测定结果以及相关性分析，明确两者联合诊断的实践价值。方法 选取青海省海南州（海拔3000m）人民医院内分泌科119例，西宁市（海拔2200m）第三人民医院内分泌科116例及上海市（海拔2.16m）复旦大学附属华山医院糖尿病研究所T2DM患者200例为糖尿病组，以及同期健康人群15例作为对照组。结果 糖尿病组患者血清五项指标表达水平均高于对照组（P<0.05）；相关性分析，血清GSP与四项指标均表现出正相关性（P<0.05）。结论 高海拔地区T2DM患者血清GSP、HbA1c均明显升高，且两者表现出正相关性。

Abstract

Objective To explore the results and correlation analysis of serum glycosylated protein (GSP) and glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes (T2DM) at high altitude, and to clarify the practical value of their combined diagnosis.
Methods 119 patients from the Department of Endocrinology of the People's Hospital of Hainan Prefecture (3000m above sea level) in Qinghai Province, 116 patients from the Department of Endocrinology of the Third People's Hospital of Xining City (2200m above sea level) and 200 patients from the diabetes Research Institute of Huashan Hospital affiliated to Fudan University in Shanghai (2.16m above sea level) were selected as the diabetes group, and 15 healthy people in the same period were selected as the control group. The data of their serum GSP, HbA1c, alanine aminotransferase (ALT), aspartate aminotransferase (AST).
Results The expression levels of five serum indexes in patients with diabetes were higher than those in the control group (P<0.05); Correlation analysis showed a positive correlation (P<0.05) between serum GSP and all four indicators.
Conclusion   Serum GSP and HbA1c levels were significantly elevated in T2DM patients in high-altitude areas, and the two showed a positive correlation.