Research on the targeted delivery system of antitumor drugs
抗肿瘤药物的靶向递送系统研究

摘要

抗肿瘤药物的靶向递送系统旨在提高治疗效果并减少副作用，是当前癌症治疗领域的一个研究热点。本论文探讨了如何通过设计和优化靶向递送系统来增强抗肿瘤药物的疗效。首先分析了传统化疗方案中存在的局限性，包括对正常细胞的高毒性以及较低的肿瘤选择性。随后，详细讨论了几种先进的靶向策略，如抗体介导的药物传递、纳米颗粒载体的应用等，并评估了这些方法在临床前和临床试验中的表现。强调了进一步优化靶向递送系统的重要性，以实现更高效、更具选择性的抗癌治疗。

Abstract

The targeted delivery system of antitumor drugs aims to improve the therapeutic effect and reduce side effects, which is a research hotspot in the current field of cancer treatment. This thesis explores how to enhance the efficacy of antitumor drugs by designing and optimizing the targeted delivery system. Firstly, the limitations of traditional chemotherapy regimens are analyzed, including high toxicity to normal cells and low tumor selectivity. Subsequently, several advanced targeted strategies, such as antibody-mediated drug delivery and the application of nanoparticle carriers, are discussed in detail, and the performance of these methods in preclinical and clinical trials is evaluated. The importance of further optimizing the targeted delivery system is emphasized to achieve more efficient and selective anticancer treatment.