Study on the clinical effect of hemodialysis combined with hemoperfusion in treating uremic skin pruritus
血液透析联合血液灌流治疗尿毒症性皮肤瘙痒的临床效果研究

摘要

目的 浅析尿毒症性皮肤瘙痒患者采用血液透析联合血液灌流治疗进行住院期指导，为患者健康生活提供建议。方法 选取2024年1月至2024年12月收治的尿毒症性皮肤瘙痒患者80例，对照组采用血液透析治疗；观察组采用血液透析联合血液灌流治疗，对比临床护理效果。结果 观察组患者皮肤瘙痒持续时间、严重程度、发作频率均优于对照组，对比差异显著（P＜0.05）；此外，观察组患者免疫功能指标改善效果优于对照组，对比差异显著（P＜0.05）。最后，观察组患者血清内毒素、β2-MG水平均在治疗后低于对照组，对比差异显著（P＜0.05）。结论 针对尿毒症性皮肤瘙痒患者在治疗过程中可以采用联合措施，在血液透析基础上，配合血液灌流方案可以更好的提升患者的免疫能力，缓解瘙痒症状，干预效果确切。

Abstract

Objective To analyze the inpatient guidance of patients with uremic pruritus with hemodialysis combined with blood perfusion therapy, and to provide suggestions for patients' healthy life.
Methods 80 patients with uremic pruritus admitted from January 2024 to December 2024 were selected, and the control group was treated with hemodialysis; the observation group used hemodialysis combined with hemoperfusion to compare the clinical nursing effect.
Results The duration, severity and attack frequency of skin pruritus in the observation group were better than those of the control group, with the significant difference (P <0.05); moreover, the immune function index in the observation group improved better than the control group, and the difference was significant (P <0.05). Finally, the serum endotoxin and β 2-MG levels in the observation group were lower than those of the control group after treatment, and the contrasts were significantly different (P <0.05).
Conclusion   Combined measures can be adopted in the treatment of patients with uremic pruritus. On the basis of hemodialysis, combined with hemoperfusion scheme can better improve the immune ability of patients, relieve pruritus symptoms, and the intervention effect is accurate.