摘要
目的 分析生物节律基因单核昔酸多态性(SNPs)与肝癌患者预后相关性。方法 选取2021年7月-2023年7月接受治疗的原发性肝细胞癌患者137例，应用SeGuenomiPLEX分型技术对所有患者进行基因分型，记录并分CRYZ基因单核昔酸多态性与肝癌患者临床治疗预后间的关联性。结果 研究对CRYZ:rsZZ9Z910进行了分层分析发现，该位点基因型与年龄超过52岁基肿瘤＜5cm患者的预后密切相关。结论 CRYZ基因单核昔酸多态性有望成为一种独立的预后指标，用肝细胞肝癌患者临床治疗后的预后评价。
关键词： 肝脏；单核昔酸多态性；肝细胞肝癌；预后；生物节律基因
Abstract
Objective To analyze the correlation between biorhythm gene mononucleic acid polymorphisms (SNPs) and prognosis of patients with liver cancer. Methods A total of 137 patients with primary hepatocellular carcinoma who received treatment from July 2021 to July 2023 were selected. SeGuenomiPLEX typing technique was used to genotype all patients, and the association between mononucleic acid polymorphism of CRYZ gene and clinical treatment prognosis of patients with hepatocellular carcinoma was recorded and separated. Results Stratified analysis of CRYZ:rsZZ9Z910 showed that this genotype was closely related to the prognosis of patients older than 52 years with basal tumors < 5cm. Conclusion CRYZ gene mononucleic acid polymorphism is expected to be an independent prognostic indicator for patients with hepatocellular carcinoma after clinical treatment.
Key words： Liver; Monocycloxylic acid polymorphism; Hepatocellular carcinoma; Prognosis; Biological rhythm gene
参考文献 References
[1] 曹梦迪,陈万青.GLOBOCAN 2022全球癌症统计数据解读[J].中国医学前沿杂志(电子版),2024,16(6):1-5.
[2] 梅文娟,李新,张昊月.超声造影时间-强度曲线相关参数鉴别诊断肝细胞癌与转移性肝癌价值研究[J].实用肝脏病杂志,2024,27(3):430-433.
[3] 古善智,黄满平,谭玉林,胡鸿涛,朱旭,郑桐森,郑振东,袁牧.多纳非尼片联合抗PD-1单抗和经导管动脉化疗栓塞术治疗不可手术切除的肝细胞癌的临床研究[J].临床肿瘤学杂志,2023,28(7):609-614.
[4] 王唯,贺小云,储明星.昼夜节律与雌激素协同调控哺乳动物生殖的研究进展[J].畜牧兽医学报,2023,54(5):1771-1781.
[5] 岑祥莹,李显,张炉英,吴瑾,钱民,胡杰,喻安永,陆元兰.白细胞介素-17介导核转录因子-κB信号通路在敌草快中毒大鼠急性肾脏损伤中的作用机制[J].中国急救医学,2021, 41(5):431-437.
[6] 郑佳南(综述),宫苹(审校).生物钟基因调控干细胞分化的研究进展[J].实用口腔医学杂志,2024,40(2):270-276.
[7] 王炳东,王慧哲,孙雷,苏天慧,张正福,邹晓.乳癌与微生物菌群失调相关性研究进展[J].青岛大学学报(医学版),2024, 60(1):155-158.
[8] 周谦君.顺“时”而为,莫让你的生物钟逆行:谈谈昼夜节律与癌症[J].科学生活,2021(11):48-49.
[9] 陈雅凡,王刚,田艺苑,同红伟,袁鹏.节律基因NPAS2在肿瘤中的研究进展[J].中国癌症防治杂志,2022,14(5):569-574.
[10] 杨柳青,石汉平.昼夜节律与肿瘤[J].肿瘤代谢与营养电子杂志,2017,4(3):338-342.