Effects of oxellidine injection on postoperative pain and serum oxidative stress in patients undergoing gynecological laparoscopic surgery
奥赛利定注射液用于妇科腹腔镜手术患者术后静脉自控镇痛对术后疼痛、血清氧化应激水平的影响

摘要

本研究旨在深入探讨奥赛利定注射液用于妇科腹腔镜手术患者术后静脉自控镇痛（PCIA）对术后疼痛、血清氧化应激水平的影响。通过选取 2024 年 1 月至 2024 年 12 月的 80 例患者，随机分为观察组（奥赛利定 PCIA）和对照组（舒芬太尼 PCIA），对比分析两组多项指标。结果显示，观察组术后各时间点疼痛评分及血清氧化应激水平低于对照组，PCIA 有效按压次数、总按压次数及不良反应发生率也更低（P<0.05）。结论表明奥赛利定注射液用于妇科腹腔镜手术术后 PCIA 可有效减轻疼痛，降低氧化应激水平且安全性良好，具有广阔临床应用前景，但仍需进一步大样本、多中心研究以完善其应用价值评估。

Abstract

The purpose of this study is to deeply investigate the effect of osidine injection on postoperative intravenous controlled analgesia (PCIA) on postoperative pain and serum oxidative stress level in patients undergoing gynecological laparoscopic surgery. By selecting 80 patients from January 2024 to December 2024, and randomly divided into observation group (Othidine PCIA) and control group (sufentanil PCIA), the two groups of multiple indicators were analyzed. The results showed that the pain score and serum oxidative stress level in the observation group were lower than that of the control group, and the number of effective PCIA presses, total presses and the incidence of adverse reactions were also lower (P <0.05). The conclusion shows that osliidin injection for PCIA after gynecological laparoscopic surgery can effectively reduce pain, reduce oxidative stress level and good safety, and has broad clinical application prospects, but further large sample and multi-center study is needed to improve its application value evaluation.