Evaluation of the efficacy of iblitt in paroxysmal atrial fibrillation in patients with coronary heart disease angina
伊布利特对冠心病心绞痛患者阵发性房颤的疗效评价

摘要

目的 评价伊布利特对合并冠心病心绞痛的房颤患者的安全性和有效性。方法 选取2023年1月至2024年8月本院收治的诊断明确为心房颤动同时伴有冠心病心绞痛患者66例。将入选患者随机对照分为两组，各33例，两组患者在常规给予冠心病常规药物治疗基础上：对照组给予胺碘酮治疗；观察组给予伊布利特治疗，比较两组合并冠心病心绞痛的心房颤动患者平均心律转复时间、转复成功率、治疗１ｈ后心电图QRS波时限、心率及QTc间期指标、心功能指标、不良反应发生情况等指标。结果 对照组及观察组治疗后心房颤动较治疗前均好转。观察组平均心律转复时间短于对照组，观察组较对照组患者转复成功率更高，有统计学意义（P<0.05）。治疗前、治疗１ｈ后心电图指标（QRS波时限、心率及QTc间期）存在差异，且观察组优于对照组，具有统计学意义（P＜0.05）。治疗后，观察组患者心功能指标优于对照组，差异有统计学意义（P<0.05）。在两组患者不良反应上未见统计学差异（P>0.05）。结论 伊布利特对合并冠心病心绞痛的房颤患者有良好的安全性和有效性，可有效促进心室功能重构，缩短转复时间，提高转复率，临床应用价值较高。

Abstract

Objective To evaluate the safety and efficacy of iibuit in patients with coronary angina.
Methods 66 patients from January 2023 to August 2024. The selected patients were divided into two groups: 33 patients each, on the basis of conventional drug therapy for coronary heart disease: the control group, the mean of patients with atrial fibrillation rotation time, success rate, ECG QRS time limit, heart rate and QTc interval index, cardiac function index, and adverse reactions.
Results The control group and the observation group were better than before treatment. The mean cardioversion time in the observation group was shorter than that in the control group, and the success rate of cardioversion was higher than that in the observation group, which was statistically significant (P <0.05). The ECG indexes (QRS time limit, heart rate and QTc interval) were different before and 1h after treatment, and the observation group was better than the control group, being statistically significant (P <0.05). After treatment, the observation group was better than the control group (P <0.05). No statistical differences in adverse reactions between the two groups (P> 0.05).
Conclusion   Ibulit has good safety and effectiveness in atrial fibrillation patients with coronary heart disease and angina pectoris, which can effectively promote ventricular functional remodeling, shorten the turning time, improve the recurrence rate, and has high clinical application value.